Stirring speed influence study on the microencapsulation process and on the drug release from microcapsules

被引：74

作者：

Jégat, C ^{[1
]}

Taverdet, JL ^{[1
]}

机构：

[1] Univ St Etienne, Fac Sci & Tech, Lab Chim & Environm, F-42023 St Etienne 2, France

来源：

POLYMER BULLETIN | 2000年 / 44卷 / 03期

关键词：

D O I：

10.1007/s002890050612

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Microparticles in the size range of 20-200 mu m, loaded with drug model were prepared by complex coacervation method. The influence of the agitation rate of dispersion on the morphology of particles and on the drug release has been studied. Obtained results show that the relationship found between the Sauter mean diameter of particles and the stirring speed of emulsification is in good agreement with the inertial breakup theory. The paper reports the preliminary results of a work intended to link up the process control parameters of the microencapsulation and the factors controlling the drug release.

引用

页码：345 / 351

页数：7

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