Behavioral assessment of visual acuity in mice and rats

被引：429

作者：

Prusky, GT

West, PWR

Douglas, RM

机构：

[1] Univ Lethbridge, Dept Psychol & Neurosci, Lethbridge, AB T1K 3M4, Canada

[2] Univ British Columbia, Dept Ophthalmol, Vancouver, BC V5Z 3N9, Canada

来源：

VISION RESEARCH | 2000年 / 40卷 / 16期

基金：

加拿大自然科学与工程研究理事会;

关键词：

visual acuity; rodent; mouse; rat; water maze;

D O I：

10.1016/S0042-6989(00)00081-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have developed a simple computer-based discrimination task that enables the quick determination of visual acuities in rodents. A grating is displayed randomly on one of two monitors at the wide end of a trapezoidal-shaped tank containing shallow water. Animals are trained to swim toward the screens, and at a fixed distance, choose the screen displaying the grating and escape to a submerged platform hidden below it. Both mice and rats learn the task quickly. Performance falls below 70% when the spatial frequency is increased beyond 0.5 cycles in most C57BU6 mice, and around 1.0 cycles per degree (cpd) in Long-Evans rats. (C) 2000 Elsevier Science Ltd. Ail rights reserved.

引用

页码：2201 / 2209

页数：9

共 47 条

[1] Transgenic and knockout mice in the study of neurodegenerative diseases [J].