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Innovation - The Connectivity Map: a new tool for biomedical research

被引：695
作者：
Lamb, Justin
机构：
[1] MIT, Broad Inst, Cambridge, MA 02142 USA
[2] Harvard Univ, Cambridge, MA 02142 USA
来源：
NATURE REVIEWS CANCER | 2007年 / 7卷 / 01期
关键词：
D O I：
10.1038/nrc2044
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The ultimate objective of biomedical research is to connect human diseases with the genes that underlie them and drugs that treat them. But this remains a daunting task, and even the most inspired researchers still have to resort to laborious screens of genetic or chemical libraries. What if at least some parts of this screening process could be systematized and centralized? And hits found and hypotheses generated with something resembling an internet search engine? These are the questions the Connectivity Map project set out to answer.
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页码：54 / 60
页数：7
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共 63 条
  • [51] Activation of the interferon system by short-interfering RNAs
    Sledz, CA
    Holko, M
    de Veer, MJ
    Silverman, RH
    Williams, BRG
    [J]. NATURE CELL BIOLOGY, 2003, 5 (09) : 834 - 839
  • [52] Drug therapy: Aromatase inhibitors in breast cancer
    Smith, IE
    Dowsett, M
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (24) : 2431 - 2442
  • [53] Clinically approved heterocyclics act on a mitochondrial target and reduce stroke-induced pathology
    Stavrovskaya, IG
    Narayanan, MV
    Zhang, WH
    Krasnikov, BF
    Heemskerk, J
    Young, SS
    Blass, JP
    Brown, AM
    Beal, MF
    Friedlander, RM
    Kristal, BS
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 200 (02) : 211 - 222
  • [54] Gefitinib induces myeloid differentiation of acute myeloid leukemia
    Stegmaier, K
    Corsello, SM
    Ross, KN
    Wong, JS
    DeAngelo, DJ
    Golub, TR
    [J]. BLOOD, 2005, 106 (08) : 2841 - 2848
  • [55] Gene expression-based high-throughput screening (GE-HTS) and application to leukemia differentiation
    Stegmaier, K
    Ross, KN
    Colavito, SA
    O'Malley, S
    Stockwell, BR
    Golub, TR
    [J]. NATURE GENETICS, 2004, 36 (03) : 257 - 263
  • [56] From knowing to controlling: A path from Genomics to drugs using small molecule probes
    Strausberg, RL
    Schreiber, SL
    [J]. SCIENCE, 2003, 300 (5617) : 294 - 295
  • [57] Large-scale analysis of the human and mouse transcriptomes
    Su, AI
    Cooke, MP
    Ching, KA
    Hakak, Y
    Walker, JR
    Wiltshire, T
    Orth, AP
    Vega, RG
    Sapinoso, LM
    Moqrich, A
    Patapoutian, A
    Hampton, GM
    Schultz, PG
    Hogenesch, JB
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (07) : 4465 - 4470
  • [58] A gene atlas of the mouse and human protein-encoding transcriptomes
    Su, AI
    Wiltshire, T
    Batalov, S
    Lapp, H
    Ching, KA
    Block, D
    Zhang, J
    Soden, R
    Hayakawa, M
    Kreiman, G
    Cooke, MP
    Walker, JR
    Hogenesch, JB
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (16) : 6062 - 6067
  • [59] Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
    Subramanian, A
    Tamayo, P
    Mootha, VK
    Mukherjee, S
    Ebert, BL
    Gillette, MA
    Paulovich, A
    Pomeroy, SL
    Golub, TR
    Lander, ES
    Mesirov, JP
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (43) : 15545 - 15550
  • [60] Small molecules, big players: The National Cancer Institute's initiative for chemical genetics
    Tolliday, Nicola
    Clemons, Paul A.
    Ferraiolo, Paul
    Koehler, Angela N.
    Lewis, Timothy A.
    Li, Xiaohua
    Schreiber, Stuart L.
    Gerhard, Daniela S.
    Eliasof, Scott
    [J]. CANCER RESEARCH, 2006, 66 (18) : 8935 - 8942
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