Fine definition of a conserved CCR5-binding region on the human immunodeficiency virus type 1 glycoprotein 120

被引：147

作者：

Rizzuto, C

Sodroski, J

机构：

[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

[3] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2000年 / 16卷 / 08期

关键词：

D O I：

10.1089/088922200308747

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A previous study implicated a conserved surface of the human immunodeficiency virus (HIV-1) gp120 exterior envelope glycoprotein in binding the CCR5 viral coreceptor (Rizzuto C, Wyatt R, Hernandez-Ramos N, Sun Y, Kwong PD, Hendrickson WA, and Sodroski J: Science 1998;280:1949-1953). Additional mutagenesis indicates that important residues in this region for CCR5 binding are Ile-420, Lys-421, Gln-422, Pro-438, and Gly-441, These highly conserved residues are located on two strands that connect the gp120 bridging sheet and outer domain, suggesting a mechanism whereby interdomain conformational shifts induced by CD4 binding could facilitate CCR5 binding.

引用

页码：741 / 749

页数：9

共 87 条

[31] CD4-independent infection by HIV-2 is mediated by Fusin/CXCR4
Endres, MJ
Clapham, PR
Marsh, M
Ahuja, M
Turner, JD
McKnight, A
Thomas, JF
StoebenauHaggarty, B
Choe, S
Vance, PJ
Wells, TNC
Power, CA
Sutterwala, SS
Doms, RW
Landau, NR
Hoxie, JA
[J]. CELL, 1996, 87 (04) : 745 - 756
[32] Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry
Farzan, M
Mirzabekov, T
Kolchinsky, P
Wyatt, R
Cayabyab, M
Gerard, NP
Gerard, C
Sodroski, J
Choe, H
[J]. CELL, 1999, 96 (05) : 667 - 676
[33] A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5
Farzan, M
Choe, H
Vaca, L
Martin, K
Sun, Y
Desjardins, E
Ruffing, N
Wu, LJ
Wyatt, R
Gerard, N
Gerard, C
Sodroski, J
[J]. JOURNAL OF VIROLOGY, 1998, 72 (02) : 1160 - 1164
[34] HIV-1 Entry Cofactor: Functional cDNA Cloing of a Seven-Transmembrane, G protein-Coupled Receptor
Feng, Yu
Broder, Christopher C.
Kennedy, Paul E.
Berger, Edward A.
[J]. JOURNAL OF IMMUNOLOGY, 2011, 186 (11) : 872 - 877
[35] PHENOTYPE-ASSOCIATED SEQUENCE VARIATION IN THE 3RD VARIABLE DOMAIN OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 GP120 MOLECULE
FOUCHIER, RAM
GROENINK, M
KOOTSTRA, NA
TERSMETTE, M
HUISMAN, HG
MIEDEMA, F
SCHUITEMAKER, H
[J]. JOURNAL OF VIROLOGY, 1992, 66 (05) : 3183 - 3187
[36] THE ROLE OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ENVELOPE GLYCOPROTEINS IN VIRUS-INFECTION
FREED, EO
MARTIN, MA
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (41) : 23883 - 23886
[37] FREQUENT DETECTION AND ISOLATION OF CYTOPATHIC RETROVIRUSES (HTLV-III) FROM PATIENTS WITH AIDS AND AT RISK FOR AIDS
GALLO, RC
SALAHUDDIN, SZ
POPOVIC, M
SHEARER, GM
KAPLAN, M
HAYNES, BF
PALKER, TJ
REDFIELD, R
OLESKE, J
SAFAI, B
WHITE, G
FOSTER, P
MARKHAM, PD
[J]. SCIENCE, 1984, 224 (4648) : 500 - 503
[38] HIV BINDING TO ITS RECEPTOR CREATES SPECIFIC EPITOPES FOR THE CD4/GP120 COMPLEX
GERSHONI, JM
DENISOVA, G
RAVIV, D
SMORODINSKY, NI
BUYANER, D
[J]. FASEB JOURNAL, 1993, 7 (12) : 1185 - 1187
[39] Envelope glycoproteins from human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus can use human CCR5 as a coreceptor for viral entry and make direct CD4-dependent interactions with this chemokine receptor
Hill, CM
Deng, HK
Unutmaz, D
Kewalramani, VN
Bastiani, L
Gorny, MK
ZollaPazner, S
Littman, DR
[J]. JOURNAL OF VIROLOGY, 1997, 71 (09) : 6296 - 6304
[40] HIV type I envelope determinants for use of the CCR2b, CCR3, STRL33, and APJ coreceptors
Hoffman, TL
Stephens, EB
Narayan, O
Doms, RW
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (19) : 11360 - 11365

← 1 2 3 4 5 6 7 8 9 →