Antigen recognition by human γδ T lymphocytes

被引：84

作者：

Kabelitz, D ^{[1
]}

Glatzel, A ^{[1
]}

Wesch, D ^{[1
]}

机构：

[1] Univ Kiel, Inst Immunol, D-24105 Kiel, Germany

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 2000年 / 122卷 / 01期

关键词：

gamma delta T cells; T cell receptor repertoire; phosphoantigens; MHC restriction; MHC class I-related chain;

D O I：

10.1159/000024353

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Mature T lymphocytes carrying the conventional alpha beta T cell receptor (TCR) recognize peptide antigens in the context of MHC class I (CD8+) and MHC class II (CD4+) antigens, respectively, In striking contrast, human gamma delta T lymphocytes recognize unconventional antigens via their heterodimeric TCR in a non-MHC-restricted fashion. In this brief review, we discuss recent progress in the identification of ligands that are specifically recognized by human gamma delta T cells. II appears that gamma delta T cells have evolved to supplement the cellular immune response towards antigens that are not seen by alpha beta T lymphocytes, Copyright (C) 2000 S. Karger AG, Basel.

引用

页码：1 / 7

页数：7

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[1] PREFERENTIAL EXPANSION OF V-GAMMA-9 V-DELTA-2 T-CELLS FOLLOWING STIMULATION OF PERIPHERAL-BLOOD LYMPHOCYTES WITH EXTRACTS OF PLASMODIUM-FALCIPARUM [J].