Conserved homeodomain proteins interact with MADS box protein Mcm1 to restrict ECB-dependent transcription to the M/G1 phase of the cell cycle

被引:131
作者
Pramila, T
Miles, S
GuhaThakurta, D
Jemiolo, D
Breeden, LL
机构
[1] Fred Hutchinson Canc Res Ctr, Div Basic Sci, Seattle, WA 98109 USA
[2] Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA
[3] Vassar Coll, Dept Biol, Poughkeepsie, NY 12604 USA
关键词
ECB; cell cycle; SWI4; CLN3; MCM2-7; transcription;
D O I
10.1101/gad.1034302
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Two homeodomain proteins, Yox1 and Yhp1, act as repressors at early cell cycle boxes (ECBs) to restrict their activity to the M/G1 phase of the cell cycle in budding yeast. These proteins bind to Mcm1 and to a typical homeodomain binding site. The expression of Yox1 is periodic and directly correlated with its binding to, and repression of, ECB activity. The absence of Yox1 and Yhp1 or the constitutive expression of Yox1 leads to the loss of cell-cycle regulation of ECB activity. Therefore, the cell-cycle-regulated expression of these repressors defines the interval of ECB-dependent transcription. Twenty-eight genes, including MCM2-7, CDC6, SWI4, CLN3, and a number of genes required during late M phase have been identified that are coordinately regulated by this pathway.
引用
收藏
页码:3034 / 3045
页数:12
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