Temporal Framing of Thalamic Relay-Mode Firing by Phasic Inhibition during the Alpha Rhythm

被引:230
作者
Loerincz, Magor L. [3 ]
Kekesi, Katalin A. [1 ,2 ]
Juhasz, Gabor [2 ]
Crunelli, Vincenzo [3 ]
Hughes, Stuart W. [3 ]
机构
[1] Eotvos Lorand Univ, Dept Physiol & Neurobiol, H-1117 Budapest, Hungary
[2] Eotvos Lorand Univ, Inst Biol, Lab Prote, H-1117 Budapest, Hungary
[3] Cardiff Univ, Sch Biosci, Cardiff CF10 3AX, S Glam, Wales
基金
英国惠康基金;
关键词
LATERAL GENICULATE-NUCLEUS; NEURONS IN-VITRO; CELLULAR MECHANISMS; AXON COLLATERALS; REACTION TIME; PERCEPTION; INTERNEURONS; OSCILLATION; POTENTIALS; DYNAMICS;
D O I
10.1016/j.neuron.2009.08.012
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Several aspects of perception, particularly those pertaining to vision, are closely linked to the occipital alpha (alpha) rhythm. However, how the alpha rhythm relates to the activity of neurons that convey primary visual information is unknown. Here we show that in behaving cats, thalamocortical neurons in the lateral geniculate nucleus (LGN) that operate in a conventional relay-mode form two groups where the cumulative firing is subject to a cyclic suppression that is centered on the negative alpha rhythm peak in one group and on the positive peak in the other. This leads to an effective temporal framing of relay-mode output and results from phasic inhibition from LGN interneurons, which in turn are rhythmically excited by thalamocortical neurons that exhibit high-threshold bursts. These results provide a potential cellular substrate for linking the alpha rhythm to perception and further underscore the central role of inhibition in controlling spike timing during cognitively relevant brain oscillations.
引用
收藏
页码:683 / 696
页数:14
相关论文
共 38 条
[21]   RELATION OF BRAIN AND TREMOR RHYTHMS TO VISUAL REACTION TIME [J].
LANSING, RW .
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1957, 9 (03) :497-504
[22]   PSYCHOLOGICAL PHENOMENA AND THE ELECTROENCEPHALOGRAM [J].
LINDSLEY, DB .
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1952, 4 (04) :443-456
[23]   ELECTROPHYSIOLOGY OF MAMMALIAN THALAMIC NEURONS INVITRO [J].
LLINAS, R ;
JAHNSEN, H .
NATURE, 1982, 297 (5865) :406-408
[25]   ORGANIZATION OF THALAMIC AND CORTICAL ALPHA RHYTHMS - SPECTRA AND COHERENCES [J].
LOPESDASILVA, FH ;
VANLIERO.TH ;
SCHRIJER, CF ;
VANLEEUW.WS .
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1973, 35 (06) :627-639
[26]   Cellular dynamics of cholinergically induced α (8-13 Hz) rhythms in sensory thalamic nuclei in vitro [J].
Lorincz, Magor L. ;
Crunelli, Vincenzo ;
Hughes, Stuart W. .
JOURNAL OF NEUROSCIENCE, 2008, 28 (03) :660-671
[27]   To See or Not to See: Prestimulus α Phase Predicts Visual Awareness [J].
Mathewson, Kyle E. ;
Gratton, Gabriele ;
Fabiani, Monica ;
Beck, Diane M. ;
Ro, Tony .
JOURNAL OF NEUROSCIENCE, 2009, 29 (09) :2725-2732
[28]   INFLUENCE OF EEG ALPHA RHYTHM ON PERCEPTION OF VISUAL-STIMULI [J].
NUNN, CMH ;
OSSELTON, JW .
PSYCHOPHYSIOLOGY, 1974, 11 (03) :294-303
[29]   PREVENTION OF CA2+-MEDIATED ACTION-POTENTIALS IN GABAERGIC LOCAL CIRCUIT NEURONS OF RAT THALAMUS BY A TRANSIENT K+ CURRENT [J].
PAPE, HC ;
BUDDE, T ;
MAGER, R ;
KISVARDAY, ZF .
JOURNAL OF PHYSIOLOGY-LONDON, 1994, 478 (03) :403-422
[30]   Rhythms in the alpha band in cats and their behavioural correlates [J].
RougeulBuser, A ;
Buser, P .
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY, 1997, 26 (1-3) :191-203