RANTES production and expression is reduced in relapsing-remitting multiple sclerosis patients treated with interferon-β-1b

被引：53

作者：

Iarlori, C

Reale, M

Lugaresi, A

De Luca, G

Bonanni, L

Di Iorio, A

Feliciani, C

Conti, P

Gambi, D

机构：

[1] Univ Gabriele DAnnunzio, Dept Oncol & Neurosci, Immunol Unit, I-66013 Chieti, Italy

[2] Univ Gabriele DAnnunzio, Dept Oncol & Neurosci, Neuroimmunol Unit, I-66013 Chieti, Italy

[3] Univ Gabriele DAnnunzio, Dept Med & Aging, I-66013 Chieti, Italy

[4] Univ Gabriele DAnnunzio, Dept Oncol & Neurosci, Dermatol Unit, I-66013 Chieti, Italy

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2000年 / 107卷 / 01期

关键词：

chemokines; RANTES; multiple sclerosis; interferon-beta; adherent monocytes; RT-PCR;

D O I：

10.1016/S0165-5728(00)00261-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

RANTES (regulated upon activation, normal T-cell expressed and secreted), a CC chemokine, appears to play a role in the pathogenesis of relapsing-remitting multiple sclerosis (RR-MS), enhancing the inflammatory response within the nervous system. We have demonstrated that RANTES production is increased in RR-MS compared to controls. Interferon-beta-1b (IFN-beta-1b) treatment reduces RANTES production in sera and peripheral blood adherent mononuclear cell (PBAM) supernatants both in relapse and remission. IFN-beta-1b also reduces RANTES expression in PBAM. Our results suggest that RANTES modulation might represent one of the mechanisms of action of IFN-beta-1b in RR-MS. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：100 / 107

页数：8

共 64 条

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