(+)-7-Bromotrypargine: an antimalarial β-carboline from the Australian marine sponge Ancorina sp.

被引：55

作者：

Davis, Rohan A. ^{[1
]}

Duffy, Sandra ^{[1
]}

Avery, Vicky M. ^{[1
]}

Camp, David ^{[1
]}

Hooper, John N. A. ^{[2
]}

Quinn, Ronald J. ^{[1
]}

机构：

[1] Griffith Univ, Eskitis Inst, Brisbane, Qld 4111, Australia

[2] Queensland Museum, Brisbane, Qld 4101, Australia

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 04期

关键词：

TROPICAL PARASITIC DISEASES; NATURAL-PRODUCTS; MANZAMINE ALKALOIDS; INDONESIAN SPONGE; (-)-TRYPARGINE; DERIVATIVES; TRYPARGINE; MALARIA;

D O I：

10.1016/j.tetlet.2009.11.055

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Mass-directed isolation of the CH2Cl2/MeOH extract from the Australian marine sponge Ancorina sp. resulted in the purification of a new antimalarial p-carboline, (+)-7-bromotrypargine 1, along with the previously isolated natural product, 6-bromotryptamine 2. The structure of I is determined by extensive 1D/2D NMR and MS data analyses. Comparison of the chiro-optical data for I with literature values of related natural products is used to determine the absolute stereochemistry of (+)-7-bromotrypargine as 1R. Antimalarial activity data for 1 and 2 against a chloroquine-resistant (Dd2) and chloroquine-sensitive (3D7) Plasmodium falciparum strain are also provided. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：583 / 585

页数：3

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