Antimalarial Benzylisoquinoline Alkaloid from the Rainforest Tree Doryphora sassafras

被引：50

作者：

Buchanan, Malcolm S. ^{[1
]}

Davis, Rohan A. ^{[1
]}

Duffy, Sandra ^{[1
]}

Avery, Vicky M. ^{[1
]}

Quinn, Ronald J. ^{[1
]}

机构：

[1] Griffith Univ, Eskitis Inst, Nathan, Qld 4111, Australia

来源：

JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 08期

关键词：

D O I：

10.1021/np9002564

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Mass-directed isolation of the CH2Cl2/MeOH extract of Doryphora sassafras resulted in the purification of a new benzylisoquinoline alkaloid, 1-(4-hydroxybenzyl)-6,7-methylenedioxy-2-methylisoquinolinium trifluoroacetate (1), and the known aporphine alkaloid (S)-isocorydine (2). The Structures of I and 2 were determined by 1D and 2D NMR and MS data analyses. The compounds were isolated during a drug discovery program aimed at identifying new antimalarial leads from a prefractionated natural product library. When tested against two different strains of the parasite Plasmodium falciparum (3D7 and Dd2), 1 displayed IC50 values of 3.0 and 4.4 mu M, respectively. Compound I was tested for cytotoxicity toward a human embryonic kidney cell line (HEK293) and displayed no activity at 120 mu M.

引用

页码：1541 / 1543

页数：3

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