Design, synthesis and antimalarial activity of benzene and isoquinoline sulfonamide derivatives

被引：54

作者：

Parai, Maloy Kumar ^{[1
]}

Panda, Gautam ^{[1
]}

Srivastava, Kumkum ^{[2
]}

Puri, Sunil Kumar ^{[2
]}

机构：

[1] Cent Drug Res Inst, Med & Proc Chem Div, Lucknow 226001, Uttar Pradesh, India

[2] Cent Drug Res Inst, Div Parasitol, Lucknow 226001, Uttar Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 02期

关键词：

benzene and isoquinoline sulfonamides; antimalarial activity;

D O I：

10.1016/j.bmcl.2007.11.038

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new series of benzene and isoquinoline sulfonamide derivatives were synthesized by nucleophilic displacement reaction on benzene and isoquinoline sulfonyl chlorides by substituted amines (primary and secondary). The title compounds were evaluated for antimalarial activity against Plasmodium falciparum in vitro and showed MIC in the range of 2-50 mu g/mL. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：776 / 781

页数：6

共 25 条

[1]

[Anonymous], 2004, BIOORG MED CHEM LETT

[2]

[Anonymous], [No title captured]

[3] Synthesis and biological evaluation of N-(7-indazolyl)benzenesulfonamide derivatives as potent cell cycle inhibitors [J].

Bouissane, L ;

El Kazzouli, S ;

Léonce, S ;

Pfeiffer, B ;

Rakib, EM ;

Khouili, M ;

Guillaumet, G .

BIOORGANIC & MEDICINAL CHEMISTRY, 2006, 14 (04) :1078-1088

[4]

Breman JG, 2001, AM J TROP MED HYG, V64, P1

[5]

CAMPBEL P, 2002, NATURE INSIGHT, V415, P6872

[6]

DOMINGUEZ JN, 2005, IL FARMACO, V60, P307

[7] Antimalarial drug discovery: Efficacy models for compound screening [J].

Fidock, DA ;

Rosenthal, PJ ;

Croft, SL ;

Brun, R ;

Nwaka, S .

NATURE REVIEWS DRUG DISCOVERY, 2004, 3 (06) :509-520

[8] In vitro study of some medicinally important Mannich bases derived from antitubercular agent [J].

Joshi, S ;

Khosla, N ;

Tiwari, P .

BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (03) :571-576

[9] Carbonic anhydrase inhibitors.: Inhibition of Plasmodium falciparum carbonic anhydrase with aromatic sulfonamides:: towards antimalarials with a novel mechanism of action? [J].

Krungkrai, J ;

Scozzafava, A ;

Reungprapavut, S ;

Krungkrai, SR ;

Rattanajak, R ;

Kamchonwongpaisan, S ;

Supuran, CT .

BIOORGANIC & MEDICINAL CHEMISTRY, 2005, 13 (02) :483-489

[10] Malarial parasite carbonic anhydrase and its inhibitors [J].

Krungkrai, Jerapan ;

Krungkrai, Sudaratana R. ;

Supuran, Claudiu T. .

CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2007, 7 (09) :909-917

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