Synthesis and biological evaluation of N-(7-indazolyl)benzenesulfonamide derivatives as potent cell cycle inhibitors

被引：127

作者：

Bouissane, L

El Kazzouli, S

Léonce, S

Pfeiffer, B

Rakib, EM

Khouili, M

Guillaumet, G

机构：

[1] Univ Orleans, CNRS, UMR 6005, Inst Chim Organ & Analyt, F-45067 Orleans 2, France

[2] Univ Cadi Ayyad, Fac Sci & Tech Beni Mellal, Beni Mellal 23000, Morocco

[3] Inst Rech Servier, Div Rec Cancerol, F-78290 Croissy Sur Seine, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 04期

关键词：

indazole; palladium; sulfonamide; L1210 murine leukemia cells;

D O I：

10.1016/j.bmc.2005.09.037

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We herein describe a new synthesis of N-(7-indazolyl)benzenesulfonamide derivatives. These Compounds were evaluated for their antiproliferative activities toward L1210 murine lukemia cells. One of them, 4-methoxy-N-(3-chloro-7-indazolyl)benzene-sulfortamide, was identified as the most potent with an IC50 of 0.44 mu M. (c) 2005 Elsevier Ltd. All rights reserved.

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页码：1078 / 1088

页数：11

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