Deliberate removal of T cell help improves virus-neutralizing antibody production

被引:75
作者
Recher, M
Lang, KS
Hunziker, L
Freigang, S
Eschli, B
Harris, NL
Navarini, A
Senn, BM
Fink, K
Lötscher, M
Hangartner, L
Zellweger, R
Hersberger, M
Theocharides, A
Hengartner, H
Zinkernagel, RM
机构
[1] Univ Zurich Hosp, Inst Expt Immunol, CH-8091 Zurich, Switzerland
[2] Univ Basel Hosp, Dept Pneumol, CH-4021 Basel, Switzerland
[3] Univ Zurich Hosp, Inst Clin Chem, CH-8091 Zurich, Switzerland
[4] Univ Basel Hosp, CH-4031 Basel, Switzerland
关键词
D O I
10.1038/ni1102
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The B cell response to lymphocytic choriomeningitis virus is characterized by a CD4(+) T cell-dependent polyclonal hypergammaglobulinemia and delayed formation of virus-specific neutralizing antibodies. Here we provide evidence that, paradoxically, because of polyclonal B cell activation, virus-specific T cell help impairs the induction of neutralizing antibody responses. Experimental reduction in CD4(+) T cell help in vivo resulted in potent neutralizing antibody responses without impairment of CD8(+) T cell activity. These unexpected consequences of polyclonal B cell activation may affect vaccine strategies and the treatment of clinically relevant chronic bacterial, parasitic and viral infections in which hypergammaglobulinemia is regularly found.
引用
收藏
页码:934 / 942
页数:9
相关论文
共 48 条
  • [1] Competitive coexistence in antiviral immunity
    Arnaout, RA
    Nowak, MA
    [J]. JOURNAL OF THEORETICAL BIOLOGY, 2000, 204 (03) : 431 - 441
  • [2] Antibody prevents the establishment of persistent arenavirus infection in synergy with endogenous T cells
    Baldridge, JR
    McGraw, TS
    Paoletti, A
    Buchmeier, MJ
    [J]. JOURNAL OF VIROLOGY, 1997, 71 (01) : 755 - 758
  • [3] Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes
    Barouch, DH
    Kunstman, J
    Kuroda, MJ
    Schmitz, JE
    Santra, S
    Peyerl, FW
    Krivulka, GR
    Beaudry, K
    Lifton, MA
    Gorgone, DA
    Montefiori, DC
    Lewis, MG
    Wolinsky, SM
    Letvin, NL
    [J]. NATURE, 2002, 415 (6869) : 335 - 339
  • [4] QUANTIFICATION OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS WITH AN IMMUNOLOGICAL FOCUS ASSAY IN 24-WELL OR 96-WELL PLATES
    BATTEGAY, M
    COOPER, S
    ALTHAGE, A
    BANZIGER, J
    HENGARTNER, H
    ZINKERNAGEL, RM
    [J]. JOURNAL OF VIROLOGICAL METHODS, 1991, 33 (1-2) : 191 - 198
  • [5] BATTEGAY M, 1993, J IMMUNOL, V151, P5408
  • [6] LYMPHOCYTIC CHORIOMENINGITIS VIRUS .6. ISOLATION OF A GLYCOPROTEIN MEDIATING NEUTRALIZATION
    BRUNS, M
    CIHAK, J
    MULLER, G
    LEHMANNGRUBE, F
    [J]. VIROLOGY, 1983, 130 (01) : 247 - 251
  • [7] Viral persistence in vivo through selection of neutralizing antibody-escape variants
    Ciurea, A
    Klenerman, P
    Hunziker, L
    Horvath, E
    Senn, BM
    Ochsenbein, AF
    Hengartner, H
    Zinkernagel, RM
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (06) : 2749 - 2754
  • [8] MONOCLONAL-ANTIBODIES FOR THE PREVENTION OF GRAFT-VERSUS-HOST DISEASE AND MARROW GRAFT-REJECTION - THE DEPLETION OF T-CELL SUBSETS INVITRO AND INVIVO
    COBBOLD, S
    MARTIN, G
    WALDMANN, H
    [J]. TRANSPLANTATION, 1986, 42 (03) : 239 - 247
  • [9] Analysis of a successful immune response against hepatitis C virus
    Cooper, S
    Erickson, AL
    Adams, EJ
    Kansopon, J
    Weiner, AJ
    Chien, DY
    Houghton, M
    Parham, P
    Walker, CM
    [J]. IMMUNITY, 1999, 10 (04) : 439 - 449
  • [10] INVOLVEMENT OF CD4+ CELLS IN LYMPHOCYTIC CHORIOMENINGITIS VIRUS-INDUCED AUTOIMMUNE ANEMIA AND HYPERGAMMAGLOBULINEMIA
    COUTELIER, JP
    JOHNSTON, SJ
    ELIDRISSI, MEA
    PFAU, CJ
    [J]. JOURNAL OF AUTOIMMUNITY, 1994, 7 (05) : 589 - 599