Deliberate removal of T cell help improves virus-neutralizing antibody production

被引:75
作者
Recher, M
Lang, KS
Hunziker, L
Freigang, S
Eschli, B
Harris, NL
Navarini, A
Senn, BM
Fink, K
Lötscher, M
Hangartner, L
Zellweger, R
Hersberger, M
Theocharides, A
Hengartner, H
Zinkernagel, RM
机构
[1] Univ Zurich Hosp, Inst Expt Immunol, CH-8091 Zurich, Switzerland
[2] Univ Basel Hosp, Dept Pneumol, CH-4021 Basel, Switzerland
[3] Univ Zurich Hosp, Inst Clin Chem, CH-8091 Zurich, Switzerland
[4] Univ Basel Hosp, CH-4031 Basel, Switzerland
关键词
D O I
10.1038/ni1102
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The B cell response to lymphocytic choriomeningitis virus is characterized by a CD4(+) T cell-dependent polyclonal hypergammaglobulinemia and delayed formation of virus-specific neutralizing antibodies. Here we provide evidence that, paradoxically, because of polyclonal B cell activation, virus-specific T cell help impairs the induction of neutralizing antibody responses. Experimental reduction in CD4(+) T cell help in vivo resulted in potent neutralizing antibody responses without impairment of CD8(+) T cell activity. These unexpected consequences of polyclonal B cell activation may affect vaccine strategies and the treatment of clinically relevant chronic bacterial, parasitic and viral infections in which hypergammaglobulinemia is regularly found.
引用
收藏
页码:934 / 942
页数:9
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