Effect of an ionic compared to a non-ionic X-ray contrast agent on platelets and coagulation during diagnostic cardiac catheterisation

被引：15

作者：

Jung, F

Spitzer, SG

Pindur, G

机构：

[1] Dresdner Inst Herz & Kreislaufforsch, D-01099 Dresden, Germany

[2] Univ Saarland, Abt Klin Hamostaseol & Transfus Med, Homburg, Germany

来源：

PATHOPHYSIOLOGY OF HAEMOSTASIS AND THROMBOSIS | 2002年 / 32卷 / 03期

关键词：

ionic; non-ionic; radiographic contrast agent; platelet function; haemostasis; ex vivo study; coronary angiography;

D O I：

10.1159/000065213

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of the present study was to evaluate the effects of ionic (ioxaglate) and non-ionic (iopromide) contrast media on haemostatic parameters ex vivo. In 40 patients undergoing coronary angiography, platelet function (platelet reactivity and serotonin concentration) and coagulation markers [thrombin-antithrombin III complexes, prothrombin fragments (F1+2) and the D-dimers] were measured. The use of an ionic X-ray contrast agent (XCA) (ioxaglate) in diagnostic cardiac catheterisation angiography is associated with lower thrombin generation and lower activation of the platelet system than when a non-ionic XCA is employed (iopromide). The results thus confirm the results of various in vitro studies and animal investigations. Copyright (C) 2002 S. Karger AG, Basel.

引用

页码：121 / 126

页数：6

共 37 条

[31]

Sakariassen KS, 1998, ACTA RADIOL, V39, P349

[32]

Scheller B, 2001, EUR HEART J, V22, P385, DOI 10.1053/euhj.2000.2319

[33] Effect of X-ray contrast media on blood flow properties after coronary angiography [J].