Transformations of glassy indomethacin induced by ball-milling

被引：43

作者：

Desprez, S.

Descamps, M.

机构：

[1] Materia Nova, Unite Physicochim Polymers, B-7000 Mons, Belgium

[2] UST Lille 1, Lab Dynam & Struct Mat Mol, Equipe Rech Technol 1018, F-59655 Villeneuve Dascq, France

来源：

JOURNAL OF NON-CRYSTALLINE SOLIDS | 2006年 / 352卷 / 42-49期

关键词：

pharmaceuticals; nucleation; polymers and organics; enthalpy relaxation; glass transition; thermodynamics;

D O I：

10.1016/j.jnoncrysol.2006.02.130

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

pharmaceutical compound was performed at room temperature. The effects of the milling intensity and duration on the physical state of the glass were investigated by X-ray powder diffraction (XRPD) and differential scanning calorimetry (DSC). Depending on the milling parameters, either we observed crystallization under milling or a modification of the physical state of the glass itself. The results are confronted with previous investigations of the effects of both the cooling rate of the melt and the physical ageing of the glass. The possibilities for milling to change the configurational state of the glassy state and the local molecular organization are discussed. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：4480 / 4485

页数：6