Antidepressant effects on kinase gene expression patterns in rat brain

被引：24

作者：

Rausch, JL ^{[1
]}

Gillespie, CF

Fei, Y

Hobby, HM

Stoming, T

Ganapathy, V

Leibach, FH

机构：

[1] Med Coll Georgia, Vet Adm, Augusta, GA 30912 USA

[2] Med Coll Georgia, Dept Psychiat, Augusta, GA 30912 USA

[3] Med Coll Georgia, Dept Hlth Behav, Augusta, GA 30912 USA

[4] Med Coll Georgia, Dept Biochem & Mol Biol, Augusta, GA 30912 USA

来源：

NEUROSCIENCE LETTERS | 2002年 / 334卷 / 02期

关键词：

antidepressants; fluoxetine; citalopram; serotonin; serotonin uptake; serotonin transporter; protein kinase; kinase; protein kinase C; cAMP-mediated protein kinase; stress-activated protein kinase; Janus protein kinase; phosphofructokinase; phosphofructokinase M;

D O I：

10.1016/S0304-3940(02)01106-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Multiple kinase pathways determine serotonin transporter (SERT) regulation. We hypothesized a decrease in kinase expression with chronic selective serotonin reuptake inhibitor (SSRI) administration necessary to regulate extracellular serotonin. We studied whole brain kinase mRNA expression on Affymetrix genechips in rats treated with placebo 3 and 21 days, fluoxetine 3 and 21 days, and citalopram 21 days. Protein kinase C (PKC)-delta, PKC-gamma, stress-activated protein kinase, cAMP-dependent protein kinase beta isoform, Janus protein kinase, and phosphofructokinase M were all down regulated chronically with citalopram and fluoxetine, but not with acute fluoxetine. The results are consistent with homeostasis of SERT function through a decrease in PK expression. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：91 / 94

页数：4

共 16 条

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