2′-amino-2′-deoxy-N6-(1-naphthylmethyl)adenosine as novel scaffold for a polymer-assisted amidation protocol

被引：17

作者：

Golisade, A

Van Calenbergh, S

Link, A

机构：

[1] Univ Hamburg, Inst Pharm, D-20146 Hamburg, Germany

[2] State Univ Ghent, Fac Farmaceut Wetenschappen, B-9000 Ghent, Belgium

来源：

TETRAHEDRON | 2000年 / 56卷 / 20期

关键词：

acylation; nucleosides; supported reagents/reactions; reduction;

D O I：

10.1016/S0040-4020(00)00228-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of a novel scaffold for the simple and high-yielding polymer-assisted solution phase preparation of arrays of 2'-amido-2'-deoxy-N-6-(1-naphthylmethyl)adenosine derivatives 10a-h as analogues of a known inhibitor of trypanosomatid glycosomal glyceraldehyde-3-phosphate dehydrogenase is described. (C) 2000 Elsevier Science Ltd. All rights reserved.

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收藏

页码：3167 / 3172

页数：6

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