Elevated serum sFlt-1/Ang-2 ratio in women with preeclampsia

被引:26
作者
Hirokoshi, Kumiko
Maeshima, Yohei
Kobayashi, Kazuko
Matsuura, Eiji
Sugiyama, Hitoshi
Yamasaki, Yasushi
Masuyama, Hisashi
Hiramatsu, Yuji
Makino, Hirofumi
机构
[1] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Med & Clin Sci, Okayama 7008558, Japan
[2] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Obstet & Gynecol, Okayama 7008558, Japan
[3] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Cell Chem, Okayama 7008558, Japan
来源
NEPHRON CLINICAL PRACTICE | 2007年 / 106卷 / 01期
关键词
angiogenesis; preeclampsia; sFlt-1; angiopoietin-2; sFlt-1/Ang-2; ratio;
D O I
10.1159/000101483
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Background: An imbalance of angiogenesis-associated factors may predispose to preeclampsia. Here, we determined the ratio of serum concentration of soluble fms-like tyrosine kinase 1 (sFlt-1), a natural inhibitor of pro-angiogenic vascular endothelial growth factor (VEGF) relative to angiopoietin-2 (Ang-2), a natural antagonist of angiopoietin-1 (Ang-1) involved in promoting angiogenesis in the presence of VEGF, in women with preeclampsia. Methods: The levels of serum sFlt-1 and Ang-2 were measured by enzyme-linked immunosorbent assay. Results: Significant decrease of serum Ang-2 and the increase of sFlt-1 were observed in women with preeclampsia as compared to healthy pregnant women. The serum sFlt-1/Ang-2 ratio was strikingly increased in preeclamptic women in contrast to healthy pregnant women exhibiting lower value similar to non-pregnant women. The serum sFlt1 concentrations tended to positively correlate with mean blood pressure (BP) in preeclamptic women, but not in healthy pregnant women. A cut-off value > 0.25 in the serum sFlt-1/Ang-2 ratio showed 87.1% sensitivity and 82.8% specificity in differentiating preeclamptic women from healthy pregnant women. Conclusion: The serum sFlt-1/Ang-2 ratio is significantly elevated in preeclamptic women as compared to healthy pregnant women. Remarkable difference of sFlt-1/Ang-2 ratio between these two groups with excellent specificity and sensitivity suggests the clinical usefulness of the serum sFlt-1/Ang-2 ratio in diagnosing and potentially predicting the onset of preeclampsia. Copyright (c) 2007 S. Karger AG, Basel.
引用
收藏
页码:C43 / C50
页数:8
相关论文
共 34 条
  • [31] Circulating levels of the antiangiogenic marker sFLT-1 are increased in first versus second pregnancies
    Wolf, M
    Shah, A
    Lam, C
    Martinez, A
    Smirnakis, KV
    Epstein, FH
    Taylor, RN
    Ecker, JL
    Karumanchi, SA
    Thadhani, R
    [J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2005, 193 (01) : 16 - 22
  • [32] Tumstatin peptide, an inhibitor of angiogenesis, prevents glomerular hypertrophy in the early stage of diabetic nephropathy
    Yamamoto, Y
    Maeshima, Y
    Kitayama, H
    Kitamura, S
    Takazawa, Y
    Sugiyama, H
    Yamasaki, Y
    Makino, H
    [J]. DIABETES, 2004, 53 (07) : 1831 - 1840
  • [33] Vascular-specific growth factors and blood vessel formation
    Yancopoulos, GD
    Davis, S
    Gale, NW
    Rudge, JS
    Wiegand, SJ
    Holash, J
    [J]. NATURE, 2000, 407 (6801) : 242 - 248
  • [34] Vascular endothelial growth factor Ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe Preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome
    Zhou, Y
    McMaster, M
    Woo, K
    Janatpour, M
    Perry, J
    Karpanen, T
    Alitalo, K
    Damsky, C
    Fisher, SJ
    [J]. AMERICAN JOURNAL OF PATHOLOGY, 2002, 160 (04) : 1405 - 1423