The synthesis of the cyclic antibacterial peptide Kawaguchipeptin B on 11 different DVB cross-linked PS resins

被引：9

作者：

Rana, S

Dubuc, J

Bradley, M ^{[1
]}

White, P

机构：

[1] Univ Southampton, Dept Chem, Southampton SO17 1BJ, Hants, England

[2] Calbiochem Novabiochem UK Ltd, Nottingham NG9 2JR, England

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 26期

关键词：

D O I：

10.1016/S0040-4039(00)00754-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report the first synthesis of the antibacterial peptide Kawaguchipeptin B. This was carried out on 11 different polystyrene resins ranging from 0.3 to 6.0% DVB cross-linking. The synthesis was accomplished using an Fmoc/Bu-t/Aloc strategy, with side chain resin attachment and a C-terminal allyl eater group for cyclisation. The syntheses of the linear and cyclic forms of the peptide were monitored and surprisingly showed that synthetic efficiency increased with increasing resin-cross linking. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：5135 / 5139

页数：5

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