Opportunistic fungi and fungal infections: the challenge of a single, general antifungal vaccine

被引:22
作者
Cassone, Antonio [1 ]
Torosantucci, Antonella [1 ]
机构
[1] Ist Super Sanita, Dept Infect Parasit & Immunomediated Dis, I-00161 Rome, Italy
关键词
antibodies; antifungal therapy; beta-glucan; passive vaccination; prevention; vaccines; CANDIDA-ALBICANS; ANTIIDIOTYPIC ANTIBODIES; SYSTEMIC CANDIDIASIS; VAGINAL CANDIDIASIS; CELL-WALL; INVASIVE ASPERGILLOSIS; PROTECTIVE IMMUNITY; MURINE CANDIDIASIS; BIOFILM FORMATION; THERAPY;
D O I
10.1586/14760584.5.6.859
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
A vaccine made up by an algal beta-glucan (laminarin), conjugated with a protein component, protects against infections by different fungi and induces antibodies capable of inhibiting fungal growth. Although taking a premium on a common molecular theme, this remains a sort of 'cross-kingdom' vaccine because the immunizing antigen and the vaccination target belong to organisms from two different kingdoms and this is certainly the first case in the field of human vaccines. Thus, it is possible to convey in a single immunological tool the potential to protect against multiple infections, in theory all those caused by beta-glucan-expressing fungi. The generation of antibodies with the potential to directly inhibit the growth of, or kill the fungal cells also opens an exciting perspective for both active and passive vaccination in immunocompromised subjects.
引用
收藏
页码:859 / 867
页数:9
相关论文
共 59 条
[1]  
[Anonymous], NOTIZIARIO I SUPERIO
[2]   Dendritic cells pulsed with fungal RNA induce protective immunity to Candida albicans in hematopoietic transplantation [J].
Bacci, A ;
Montagnoli, C ;
Perruccio, K ;
Bozza, S ;
Gaziano, R ;
Pitzurra, L ;
Velardi, A ;
d'Ostiani, CF ;
Cutler, JE ;
Romani, L .
JOURNAL OF IMMUNOLOGY, 2002, 168 (06) :2904-2913
[3]   Dendritic cell-based vaccination against opportunistic fungi [J].
Bozza, S ;
Montagnoli, C ;
Gaziano, R ;
Rossi, G ;
Nkwanyuo, G ;
Bellocchio, S ;
Romani, L .
VACCINE, 2004, 22 (07) :857-864
[4]   Interplay between protective and inhibitory antibodies dictates the outcome of experimentally disseminated candidiasis in recipients of a Candida albicans vaccine [J].
Bromuro, C ;
Torosantucci, A ;
Chiani, P ;
Conti, S ;
Polonelli, L ;
Cassone, A .
INFECTION AND IMMUNITY, 2002, 70 (10) :5462-5470
[5]   Fungal β-glucans and mammalian immunity [J].
Brown, GD ;
Gordon, S .
IMMUNITY, 2003, 19 (03) :311-315
[6]  
Cárdenas-Freytag L, 1999, INFECT IMMUN, V67, P826
[7]   Polysaccharide-containing conjugate vaccines for fungal diseases [J].
Casadevall, A ;
Pirofski, UA .
TRENDS IN MOLECULAR MEDICINE, 2006, 12 (01) :6-9
[8]   Passive antibody therapy for infectious diseases [J].
Casadevall, A ;
Dadachova, E ;
Pirofski, L .
NATURE REVIEWS MICROBIOLOGY, 2004, 2 (09) :695-703
[9]   Induced humoral immunity and vaccination against major human fungal pathogens [J].
Casadevall, A ;
Feldmesser, M ;
Pirofski, LA .
CURRENT OPINION IN MICROBIOLOGY, 2002, 5 (04) :386-391
[10]   Antibodies, killer toxins and antifungal immunoprotection: A lesson from nature [J].
Cassone, A ;
Conti, S ;
DeBernardis, F ;
Polonelli, L .
IMMUNOLOGY TODAY, 1997, 18 (04) :164-169