Bax, along with lipid conspirators, allows cytochrome c to escape mitochondria

被引：41

作者：

Hardwick, JM ^{[1
]}

Polster, BM ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA

来源：

MOLECULAR CELL | 2002年 / 10卷 / 05期

关键词：

D O I：

10.1016/S1097-2765(02)00751-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bax and cleaved Bid trigger cytochrome c release from mitochondria during apoptosis. Recent work demonstrates that mitochondrial lipid rather than protein composition is the key determinant in the permeabilization process via a supramolecular complex, suggesting a reevaluation of current paradigms.

引用

页码：963 / 965

页数：3

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