Detection of Novel Sequences Related to African Swine Fever Virus in Human Serum and Sewage

被引：37

作者：

Loh, Joy ^{[1
,2
]}

Zhao, Guoyan ^{[1
,2
]}

Presti, Rachel M. ^{[3
]}

Holtz, Lori R. ^{[4
]}

Finkbeiner, Stacy R. ^{[1
,2
]}

Droit, Lindsay ^{[1
,2
]}

Villasana, Zoilmar ^{[1
,2
]}

Todd, Collin ^{[1
,2
]}

Pipas, James M. ^{[5
]}

Calgua, Byron ^{[6
]}

Girones, Rosina ^{[6
]}

Wang, David ^{[1
,2
]}

Virgin, Herbert W. ^{[1
,2
]}

机构：

[1] Washington Univ, Dept Pathol & Immunol, Sch Med, St Louis, MO 63110 USA

[2] Washington Univ, Dept Mol Microbiol, Sch Med, St Louis, MO 63110 USA

[3] Washington Univ, Dept Med, Sch Med, St Louis, MO 63110 USA

[4] Washington Univ, Dept Pediat, Sch Med, St Louis, MO 63110 USA

[5] Univ Pittsburgh, Dept Biol Sci, Pittsburgh, PA 15260 USA

[6] Univ Barcelona, Fac Biol, Dept Microbiol, Barcelona, Spain

来源：

JOURNAL OF VIROLOGY | 2009年 / 83卷 / 24期

基金：

美国国家卫生研究院;

关键词：

NUCLEOTIDE-SEQUENCE; GENE; PROTEINS; HOMOLOGY; ORIGIN; IDENTIFICATION; EPIDEMIOLOGY; EVOLUTION; MIMIVIRUS; ENCODES;

D O I：

10.1128/JVI.00638-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The family Asfarviridae contains only a single virus species, African swine fever virus (ASFV). ASFV is a viral agent with significant economic impact due to its devastating effects on populations of domesticated pigs during outbreaks but has not been reported to infect humans. We report here the discovery of novel viral sequences in human serum and sewage which are clearly related to the asfarvirus family but highly divergent from ASFV. Detection of these sequences suggests that greater genetic diversity may exist among asfarviruses than previously thought and raises the possibility that human infection by asfarviruses may occur.

引用

页码：13019 / 13025

页数：7

共 29 条

[1] Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
Altschul, SF
Madden, TL
Schaffer, AA
Zhang, JH
Zhang, Z
Miller, W
Lipman, DJ
[J]. NUCLEIC ACIDS RESEARCH, 1997, 25 (17) : 3389 - 3402
[2] Genotyping field strains of African swine fever virus by partial p72 gene characterisation
Bastos, ADS
Penrith, ML
Crucière, C
Edrich, JL
Hutchings, G
Roger, F
Couacy-Hymann, E
Thomson, GR
[J]. ARCHIVES OF VIROLOGY, 2003, 148 (04) : 693 - 706
[3] AFRICAN SWINE FEVER VIRUS ENCODES A GENE WITH EXTENSIVE HOMOLOGY TO TYPE-II DNA TOPOISOMERASES
BAYLIS, SA
DIXON, LK
VYDELINGUM, S
SMITH, GL
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1992, 228 (03) : 1003 - 1010
[4] Genetic characterisation of African swine fever viruses from outbreaks in southern Africa (1973-1999)
Boshoff, C. I.
Bastos, A. D. S.
Gerber, L. J.
Vosloo, W.
[J]. VETERINARY MICROBIOLOGY, 2007, 121 (1-2) : 45 - 55
[5] Comparison of the genome sequences of nonpathogenic and pathogenic African swine fever virus isolates
Chapman, David A. G.
Tcherepanov, Vasily
Upton, Chris
Dixon, Linda K.
[J]. JOURNAL OF GENERAL VIROLOGY, 2008, 89 : 397 - 408
[6] Claverie JM, 2009, CURR TOP MICROBIOL, V328, P89
[7] African swine fever virus proteins involved in evading host defence systems
Dixon, LK
Abrams, CC
Bowick, G
Goatley, LC
Kay-Jackson, PC
Chapman, D
Liverani, E
Nix, R
Silk, R
Zhang, FQ
[J]. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 2004, 100 (3-4) : 117 - 134
[8] A GENE HOMOLOGOUS TO TOPOISOMERASE-II IN AFRICAN SWINE FEVER VIRUS
GARCIABEATO, R
FREIJE, JMP
LOPEZOTIN, C
BLASCO, R
VINUELA, E
SALAS, ML
[J]. VIROLOGY, 1992, 188 (02) : 938 - 947
[9] HEUSCHELE W P, 1969, Bulletin of Epizootic Diseases of Africa, V17, P179
[10] Evolutionary genomics of nucleo-cytoplasmic large DNA viruses
Iyer, LA
Balaji, S
Koonin, EV
Aravind, L
[J]. VIRUS RESEARCH, 2006, 117 (01) : 156 - 184

← 1 2 3 →