Quantitative evaluation of the relative cell permeability of peptoids and peptides

被引：163

作者：

Kwon, Yong-Uk

Kodadek, Thomas

机构：

[1] Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX 75390 USA

[2] Univ Texas, SW Med Ctr, Div Translat Res, Dallas, TX 75390 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 06期

关键词：

D O I：

10.1021/ja0668623

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We evaluated quantitatively the relative cell permeability of peptides and peptides using a cell-based reporter gene-based assay. Generally, peptoids were much more cell permeable than the corresponding peptides, though the difference decreased with increasing length. These results suggest that peptoids may be useful reagents for manipulating the activities of intracellular proteins.

引用

收藏

页码：1508 / +

页数：3

相关论文

共 12 条

[1] Converting a peptide into a drug: Strategies to improve stability and bioavailability [J].

Adessi, C ;

Soto, C .

CURRENT MEDICINAL CHEMISTRY, 2002, 9 (09) :963-978

[2] Isolation of protein ligands from large peptoid libraries [J].

Alluri, PG ;

Reddy, MM ;

Bachhawat-Sikder, K ;

Olivos, HJ ;

Kodadek, T .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (46) :13995-14004

[3] Probing the structural requirements of peptoids that inhibit HDM2-p53 interactions [J].

Hara, T ;

Durell, SR ;

Myers, MC ;

Appella, DH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (06) :1995-2004

[4] A threaded loop conformation adopted by a family of peptoid nonamers [J].

Huang, K ;

Wu, CW ;

Sanborn, TJ ;

Patch, JA ;

Kirshenbaum, K ;

Zuckermann, RN ;

Barron, AE ;

Radhakrishnan, I .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (05) :1733-1738

[5] Simple reporter gene-based assays for hairpin poly(amide) conjugate permeability and DNA-binding activity in living cells [J].

Liu, Bo ;

Yu, Peng ;

Alluri, Prasanna G. ;

Kodadek, Thomas .

MOLECULAR BIOSYSTEMS, 2005, 1 (04) :307-317

[6] Peptoids as source of compounds eliciting antibacterial activity [J].

Masip, I ;

Pérez-Paya, E ;

Messeguer, A .

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, 2005, 8 (03) :235-239

[7] COMPARISON OF THE PROTEOLYTIC SUSCEPTIBILITIES OF HOMOLOGOUS L-AMINO-ACID, D-AMINO-ACID, AND N-SUBSTITUTED GLYCINE PEPTIDE AND PEPTOID OLIGOMERS [J].

MILLER, SM ;

SIMON, RJ ;

NG, S ;

ZUCKERMANN, RN ;

KERR, JM ;

MOOS, WH .

DRUG DEVELOPMENT RESEARCH, 1995, 35 (01) :20-32

[8] Microwave-assisted solid-phase synthesis of peptoids [J].

Olivos, HJ ;

Alluri, PG ;

Reddy, MM ;

Salony, D ;

Kodadek, T .

ORGANIC LETTERS, 2002, 4 (23) :4057-4059

[9] Mimicry of bioactive peptides via non-natural, sequence-specific peptidomimetic oligomers [J].

Patch, JA ;

Barron, AE .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2002, 6 (06) :872-877

[10] Protein "fingerprinting" in complex mixtures with peptoid microarrays [J].

Reddy, MM ;

Kodadek, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (36) :12672-12677