Mimicry of bioactive peptides via non-natural, sequence-specific peptidomimetic oligomers

被引：240

作者：

Patch, JA ^{[1
]}

Barron, AE ^{[1
]}

机构：

[1] Northwestern Univ, Dept Chem Engn, Evanston, IL 60208 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2002年 / 6卷 / 06期

关键词：

D O I：

10.1016/S1367-5931(02)00385-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Non-natural, sequence-specific peptidomimetic oligomers are being designed to mimic bioactive peptides, with potential therapeutic application. Cationic, facially amphipathic helical beta-peptide oligomers have been developed as magainin mimetics. Non-natural mimics of HIV-Tat protein, lung surfactant proteins, collagen, and somatostatin are also being developed. Pseudo-tertiary structure in beta-peptides and peptoids may herald the creation of entirely artificial proteins.

引用

页码：872 / 877

页数：6

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