Retinoid signaling regulates breast cancer stem cell differentiation

被引：188

作者：

Ginestier, Christophe ^{[1
]}

Wicinski, Julien ^{[1
]}

Cervera, Nathalie ^{[1
]}

Monville, Florence ^{[1
]}

Finetti, Pascal ^{[1
]}

Bertucci, Francois ^{[1
]}

Wicha, Max S. ^{[2
]}

Birnbaum, Daniel ^{[1
]}

Charafe-Jauffret, Emmanuelle ^{[1
]}

机构：

[1] Inst J Paoli I Calmettes, INSERM, UMR891, Ctr Rech Cancerol Marseille,Lab Oncol Mol, Marseilles, France

[2] Univ Michigan, Dept Internal Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

来源：

CELL CYCLE | 2009年 / 8卷 / 20期

关键词：

cancer stem cell; breast cancer; retinoid signaling; ALDH; tumor-sphere; gene set enrichment analysis; ALDEHYDE DEHYDROGENASE; ACID RECEPTOR; GENE; APOPTOSIS; TUMORS; ALPHA; BETA;

D O I：

10.4161/cc.8.20.9761

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The cancer stem cell (CSC) hypothesis implicates the development of new therapeutic approaches to target the CSC population. Characterization of the pathways that regulate CSCs activity will facilitate the development of targeted therapies. We recently reported that the enzymatic activity of ALDH1, as measured by the ALDELFUOR assay, can be utilized to isolate normal and malignant breast stem cells in both primary tumors and cell lines. In this study, utilizing a tumorsphere assay, we have demonstrated the role of retinoid signaling in the regulation of breast CSCs self-renewal and differentiation. Utilizing the gene set enrichment analysis (GSEA) algorithm we identified gene sets and pathways associated with retinoid signaling. These pathways regulate breast CSCs biology and their inhibition may provide novel therapeutic approaches to target breast CSCs.

引用

页码：3297 / 3302

页数：6