B-cell activity of polyclonal antithymocyte globulins

被引：45

作者：

Zand, Martin S. ^{[1
]}

机构：

[1] Univ Rochester, Med Ctr, Div Nephrol, Rochester, NY 14642 USA

来源：

TRANSPLANTATION | 2006年 / 82卷 / 11期

关键词：

polyclonal antilymphocyte serum; plasma cell; B cell; apoptosis; alloantibodies;

D O I：

10.1097/01.tp.0000244063.05338.27

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Polyclonal antithymocyte globulins (AThG) are a subset of antilymphocyte antibody preparations derived from the sera of rabbits or horses immunized with unfractionated cells isolated from pediatric human thymi. In vivo, AThG preparations have been used to successfully treat antibody mediated rejection in kidney transplant recipients. In vitro, AThG can induce apoptosis of naive and memory B cells and terminally differentiated plasma cells. The presence of B-cell reactive antibodies in AThG results from a thymic inoculum containing a significant percentage of CD20+ B cells and CD138+ plasma cells. In this paper, the experimental and clinical evidence supporting the B-cell activity of AThG preparations, and their mechanisms of action, are reviewed.

引用

页码：1387 / 1395

页数：9

共 119 条

[81]

Neumann MC, 1996, CLIN NEPHROL, V45, P345

[82] Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodies [J].

Ober, RJ ;

Radu, CG ;

Ghetie, V ;

Ward, ES .

INTERNATIONAL IMMUNOLOGY, 2001, 13 (12) :1551-1559

[83] LONG-TERM OUTCOME OF APLASTIC-ANEMIA IN ADULTS TREATED WITH ANTITHYMOCYTE GLOBULIN - COMPARISON WITH BONE-MARROW TRANSPLANTATION [J].

PAQUETTE, RL ;

TEBYANI, N ;

FRANE, M ;

IRELAND, P ;

HO, WG ;

CHAMPLIN, RE ;

NIMER, SD .

BLOOD, 1995, 85 (01) :283-290

[84]

PESCOVITZ MD, 1994, SURGERY, V116, P811

[85] A quantitative flow cytometry assay for the preclinical testing and pharmacological monitoring of rabbit antilymphocyte globulins (rATG) [J].

Préville, X ;

Nicolas, L ;

Flacher, M ;

Revillard, JP .

JOURNAL OF IMMUNOLOGICAL METHODS, 2000, 245 (1-2) :45-54

[86] Mechanisms involved in antithymocyte globulin immuno suppressive activity in a nonhuman primate model [J].

Préville, X ;

Flacher, M ;

LeMauff, B ;

Beauchard, S ;

Davelu, P ;

Tiollier, J ;

Revillard, JP .

TRANSPLANTATION, 2001, 71 (03) :460-468

[87] Regulation of inherently autoreactive VH4-34B cells in the maintenance of human B cell tolerance [J].

Pugh-Bernard, AE ;

Silverman, GJ ;

Cappione, AJ ;

Villano, ME ;

Ryan, DH ;

Insel, RA ;

Sanz, I .

JOURNAL OF CLINICAL INVESTIGATION, 2001, 108 (07) :1061-1070

[88] Antibody-mediated rejection criteria - an addition to the Banff '97 Classification of Renal Allograft Rejection [J].

Racusen, LC ;

Colvin, RB ;

Solez, K ;

Mihatsch, MJ ;

Halloran, PF ;

Campbell, PM ;

Cecka, MJ ;

Cosyns, JP ;

Demetris, AJ ;

Fishbein, MC ;

Fogo, A ;

Furness, P ;

Gibson, IW ;

Glotz, D ;

Hayry, P ;

Hunsickern, LN ;

Kashgarian, M ;

Kerman, R ;

Magil, AJ ;

Montgomery, R ;

Morozumi, K ;

Nickeleit, V ;

Randhawa, P ;

Regele, H ;

Seron, D ;

Seshan, S ;

Sund, S ;

Trpkov, K .

AMERICAN JOURNAL OF TRANSPLANTATION, 2003, 3 (06) :708-714

[89]

RAEFSKY EL, 1986, BLOOD, V68, P712

[90] IgG Fc receptors [J].

Ravetch, JV ;

Bolland, S .

ANNUAL REVIEW OF IMMUNOLOGY, 2001, 19 :275-290

← 3 4 5 6 7 8 9 10 11 12 →