Zinc tetraruthenated porphyrin binding and photoinduced oxidation of calf-thymus DNA

被引：43

作者：

Araki, K ^{[1
]}

Silva, CA ^{[1
]}

Toma, HE ^{[1
]}

Catalani, LH ^{[1
]}

Medeiros, MHG ^{[1
]}

Di Mascio, P ^{[1
]}

机构：

[1] Univ Sao Paulo, Inst Quim, BR-05599970 Sao Paulo, SP, Brazil

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2000年 / 78卷 / 04期

基金：

巴西圣保罗研究基金会;

关键词：

tetraruthenated porphyrin; photooxidation; PDT sensitizer; DNA;

D O I：

10.1016/S0162-0134(00)00053-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The photooxidation of calf-thymus DNA has been investigated in the presence of a supramolecular tetraruthenated zincporphyrin (ZnTRP) sensitizer. A strong interaction of ZnTRP with DNA has been observed, exhibiting a gradual transition from a non-specific electrostatic binding mode to a more specific one at high DNA concentrations. Formation of O-2((1)Delta(g)) has been detected from its near-infrared emission, after the excitation of ZnTRP in dioxygen-containing solutions. In the presence of DNA and dioxygen, ZnTRP promotes efficient photocatalytic oxidation of the 2'-deoxyguanosine sites, via their direct reaction with O-2((1)Delta(g)), as in a previous work on the ZnTRP-photoinduced oxidation of the free nucleosides. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：269 / 273

页数：5

共 29 条

[1] Type I and type II photosensitized oxidative modification of 2'-deoxyguanosine (dGuo) by triplet-excited ketones generated thermally from the 1,2-dioxetane HTMD [J].

Adam, W ;

SahaMoller, CR ;

Schonberger, A .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (04) :719-723

[2] LUMINESCENCE, SPECTROELECTROCHEMISTRY AND PHOTOELECTROCHEMICAL PROPERTIES OF A TETRARUTHENATED ZINC PORPHYRIN [J].

ARAKI, K ;

TOMA, HE .

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 1994, 83 (03) :245-250

[3]

Barnes NR, 1998, J INORG BIOCHEM, V72, P1

[4] INTERCALATIVE AND NONINTERCALATIVE BINDING OF LARGE CATIONIC PORPHYRIN LIGANDS TO CALF THYMUS DNA [J].

CARVLIN, MJ ;

FIEL, RJ .

NUCLEIC ACIDS RESEARCH, 1983, 11 (17) :6121-6139

[5] Photodynamic therapy [J].

Dougherty, TJ ;

Gomer, CJ ;

Henderson, BW ;

Jori, G ;

Kessel, D ;

Korbelik, M ;

Moan, J ;

Peng, Q .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1998, 90 (12) :889-905

[6] INTERACTION OF DNA WITH A PORPHYRIN LIGAND - EVIDENCE FOR INTERCALATION [J].

FIEL, RJ ;

HOWARD, JC ;

MARK, EH ;

DATTAGUPTA, N .

NUCLEIC ACIDS RESEARCH, 1979, 6 (09) :3093-3118

[7] PORPHYRIN - NUCLEIC-ACID INTERACTIONS - A REVIEW [J].

FIEL, RJ .

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 1989, 6 (06) :1259-1275

[8] DEFINITION OF TYPE-I AND TYPE-II PHOTOSENSITIZED OXIDATION [J].

FOOTE, CS .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1991, 54 (05) :659-659

[9]

GORMAN AA, 1989, HDB ORGANIC PHOTOCHE, V2, P229

[10] HOW DOES PHOTODYNAMIC THERAPY WORK [J].

HENDERSON, BW ;

DOUGHERTY, TJ .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1992, 55 (01) :145-157

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