The diversity of Rab proteins in vesicle transport

被引:673
作者
Novick, P [1 ]
Zerial, M [1 ]
机构
[1] EUROPEAN MOL BIOL LAB,D-69012 HEIDELBERG,GERMANY
关键词
D O I
10.1016/S0955-0674(97)80025-7
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Rab proteins have been primarily implicated in vesicle docking as regulators of SNARE pairing. Recent findings, however, indicate that their function in vesicle trafficking can go beyond this role, and a number of proteins, unrelated to each other, have been identified as putative Rab effectors. Although the GTPase switch of Rab proteins is highly conserved, functional mechanisms may be highly diversified among members of the Rab family.
引用
收藏
页码:496 / 504
页数:9
相关论文
共 78 条
[51]   Nucleotide dependence of Rab geranylgeranylation - Rab escort protein interacts preferentially with GDP-bound Rab [J].
Seabra, MC .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (24) :14398-14404
[52]  
Shen F, 1996, J BIOL CHEM, V271, P3692
[53]   RABPHILIN-3A, A PUTATIVE TARGET PROTEIN FOR SMG P25A RAB3A P25 SMALL GTP-BINDING PROTEIN RELATED TO SYNAPTOTAGMIN [J].
SHIRATAKI, H ;
KAIBUCHI, K ;
SAKODA, T ;
KISHIDA, S ;
YAMAGUCHI, T ;
WADA, K ;
MIYAZAKI, M ;
TAKAI, Y .
MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (04) :2061-2068
[54]  
SHIRATAKI H, 1994, J BIOL CHEM, V269, P32717
[55]   CLONING, CHARACTERIZATION, AND EXPRESSION OF A NOVEL GDP DISSOCIATION INHIBITOR ISOFORM FROM SKELETAL-MUSCLE [J].
SHISHEVA, A ;
SUDHOF, TC ;
CZECH, MP .
MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (05) :3459-3468
[56]   RAB PROTEINS AND THE ROAD MAPS FOR INTRACELLULAR-TRANSPORT [J].
SIMONS, K ;
ZERIAL, M .
NEURON, 1993, 11 (05) :789-799
[57]  
SINGERKRUGER B, 1995, J CELL SCI, V108, P3509
[58]   ROLE OF 3 RAB5-LIKE GTPASES, YPT51P, YPT52P, AND YPT53P, IN THE ENDOCYTIC AND VACUOLAR PROTEIN SORTING PATHWAYS OF YEAST [J].
SINGERKRUGER, B ;
STENMARK, H ;
DUSTERHOFT, A ;
PHILIPPSEN, P ;
YOO, JS ;
GALLWITZ, D ;
ZERIAL, M .
JOURNAL OF CELL BIOLOGY, 1994, 125 (02) :283-298
[59]   A RAB PROTEIN IS REQUIRED FOR THE ASSEMBLY OF SNARE COMPLEXES IN THE DOCKING OF TRANSPORT VESICLES [J].
SOGAARD, M ;
TANI, K ;
YE, RR ;
GEROMANOS, S ;
TEMPST, P ;
KIRCHHAUSEN, T ;
ROTHMAN, JE ;
SOLLNER, T .
CELL, 1994, 78 (06) :937-948
[60]   MEMBRANE TARGETING OF THE SMALL GTPASE RAB9 IS ACCOMPANIED BY NUCLEOTIDE EXCHANGE [J].
SOLDATI, T ;
SHAPIRO, AD ;
SVEJSTRUP, ABD ;
PFEFFER, SR .
NATURE, 1994, 369 (6475) :76-78