Antimalarial activity of yingzhaosu A analogues

被引：18

作者：

Kim, HS

Begum, H

Ogura, N

Wataya, Y ^{[1
]}

Tokuyasu, T

Masuyama, A

Nojima, M

McCullough, KJ

机构：

[1] Okayama Univ, Fac Pharmaceut Sci, Okayama 7008530, Japan

[2] Osaka Univ, Fac Engn, Dept Chem Mat, Suita, Osaka 5650871, Japan

[3] Heriot Watt Univ, Dept Chem, Edinburgh EH14 4AS, Midlothian, Scotland

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2002年 / 45卷 / 21期

关键词：

D O I：

10.1021/jm020208q

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Iodonium ion mediated cyclization of unsaturated hydroperoxides 1 afforded the expected yingzhaosu A analogues 2. In some cases, however, the corresponding cyclic ethers 5 were formed competitively with the cyclic peroxides 2, the ratios of these two products being a marked function of the structure of the starting materials. Some of the cyclic peroxides 2 showed significant antimalarial activities in vitro and in vivo.

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收藏

页码：4732 / 4736

页数：5

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