Acid catalyzed Michael additions to artemisitene

被引：30

作者：

Ma, JY

Weiss, E

Kyle, DE

Ziffer, H ^{[1
]}

机构：

[1] NIDDK, Chem Phys Lab, Bethesda, MD 20892 USA

[2] NIDDK, Bioorgan Chem Lab, Bethesda, MD 20892 USA

[3] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Dept Parasitol, Washington, DC 20307 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 14期

关键词：

D O I：

10.1016/S0960-894X(00)00297-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 14-substituted-artemisinin and 9-epiartemisinin derivatives was prepared by a titanium-tetrachloride catalyzed addition of trimethylsilyl enol ethers to artemisitene. Several compounds were four to seven times more active than artemisinin against Plasmodium falciparum. (C) 2000 Published by Elsevier Science Ltd. All rights reserved.

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页码：1601 / 1603

页数：3

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