Nanostructured lipid carriers-containing anticancer compounds: Preparation, characterization, and cytotoxicity studies

被引：56

作者：

Bondi, Maria Luisa

Craparo, Emanuela Fabiola

Giammona, Gaetano

Cervello, Melchiorre

Azzolina, Antonina

Diana, Patrizia

Martorana, Anna

Cirrincione, Girolatno

机构：

[1] CNR, Ist Studio Mat Nanostrutturati, Sez Palermo, I-90146 Palermo, Italy

[2] CNR, Ist Biomed & Immunol Mol Alberto Monriy, I-90146 Palermo, Italy

[3] Univ Palermo, Dipartimento Chim & Tecnol Farmaceut, I-90133 Palermo, Italy

[4] Univ Palermo, Dipartimento Farmacochim Tossicol & Biol, I-90133 Palermo, Italy

来源：

DRUG DELIVERY | 2007年 / 14卷 / 02期

关键词：

antitumor drugs; controlled release; human hepatocellular carcinoma cells; human prostate carcinoma cells; nanostructured lipid carrier;

D O I：

10.1080/10717540600739914

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This article describes the development of nanostructured lipid carriers (NLC) as colloidal carriers for two antitumor compounds that possess a remarkable antineoplastic activity. But their limited stability and low solubility in water could give a very low parenteral bioavailability. Results revealed an enhancement of the cytotoxicity effect of drug-loaded NLC on human prostate cancer (PC-3) and human hepatocellular carcinoma (HuH-6, HuH-7) cell lines with respect to that of both free drugs. Results of characterization studies strongly support the potential application of these drugs-loaded NLC as prolonged delivery systems for lipophilic drugs by several administration routes, in particular for intravenous administration.

引用

页码：61 / 67

页数：7

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[11] Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review [J].