The effects of forced exercise on hippocampal plasticity in the rat: A comparison of LTP, spatial- and non-spatial learning

被引：206

作者：

O'Callaghan, Rachel M.

Ohle, Robert

Kelly, Aine M. ^{[1
]}

机构：

[1] Univ Dublin Trinity Coll, Sch Med, Dept Physiol, Dublin 2, Ireland

[2] Univ Dublin Trinity Coll, Inst Neurosci, Dublin 2, Ireland

来源：

BEHAVIOURAL BRAIN RESEARCH | 2007年 / 176卷 / 02期

关键词：

exercise; BDNF; hippocampus spatial learning; LTP; object recognition;

D O I：

10.1016/j.bbr.2006.10.018

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Physical activity may have the potential to improve cognitive function. Here we show that forced treadmill-running results in selective improvements in hippocampal plasticity. Rats that underwent exercise training demonstrated enhanced expression of long-term potentiation in dentate gyrus and enhanced object recognition learning. Spatial learning in the Morris watermaze was unaffected by exercise. These changes were associated with an increase in expression of brain-derived neurotrophic factor in the dentate gyrus. (c) 2006 Elsevier B.V. All rights reserved.

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页码：362 / 366

页数：5

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