A spatial scan statistic for survival data

被引:118
作者
Huang, Lan
Kulldorff, Martin
Gregorio, David
机构
[1] NCI, Stat Res & Applicat Branch, Div Canc Control & Populat Sci, Rockville, MD 20852 USA
[2] Harvard Univ, Sch Med, Dept Ambulatory Care & Prevent, Boston, MA 02215 USA
[3] Harvard Pilgrim Hlth Care, Boston, MA 02215 USA
[4] Univ Connecticut, Sch Med, Dept Community Med, Farmington, CT 06030 USA
关键词
censoring; covariate adjustment; exponential model; geographical surveillance; spatial scan statistic; survival data;
D O I
10.1111/j.1541-0420.2006.00661.x
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Spatial scan statistics with Bernoulli and Poisson models are commonly used for geographical disease surveillance and cluster detection. These models. suitable for count data were not designed for data with continuous outcomes. We propose a spatial scan statistic based on an exponential model to handle either uncensored or censored continuous survival data. The power and sensitivity of the developed model are investigated through intensive simulations. The method performs well for different survival distribution finictious including tile exponential, gainnia, and log-norinal distributions. We also present a method to adjust the analysis for covariates. The cluster detection rnethod is illustrated rising survival data for inen diagnosed with prostate cancer in Connecticut from 1984 to 1995.
引用
收藏
页码:109 / 118
页数:10
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