Chemogenomics: Bridging a drug discovery gap

被引:23
作者
Bleicher, KH [1 ]
机构
[1] F Hoffmann La Roche Ltd, Div Pharmaceut, CH-4070 Basel, Switzerland
关键词
target identification; target validation; library design; virtual screening; chemogenomics;
D O I
10.2174/0929867023368728
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
With the Successful completion of the human genome sequencing and the resulting plethora of genetic information now available novel technologies and applications have to be established to translate the huge amount of data generated into successful biological and biomedical research programs. The integration of various drug discovery disciplines within the parallel quest for novel targets and new molecular entities has meanwhile given rise to a quite popular term in pharmaceutical research named "chemogenomics". This review article gives an overview of the disciplines involved in this field and discusses the possible implications of this novel paradigm in drug discovery for the near future.
引用
收藏
页码:2077 / 2084
页数:8
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