Anthrax X-rayed: new opportunities for biodefence

被引：10

作者：

Stubbs, MT ^{[1
]}

机构：

[1] Univ Halle Wittenberg, Inst Biotechnol, D-06120 Halle Saale, Germany

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2002年 / 23卷 / 12期

关键词：

D O I：

10.1016/S0165-6147(02)02127-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Bacillus anthracis, the agent responsible for inhalation anthrax, exerts its lethal effects via the production of anthrax toxin (protective antigen, lethal factor and oedema factor); anthrax kills because the toxin overwhelms the patient before innate host defence systems have a chance to eradicate the invaders. Structural studies on these three components provide a starting point for the design of novel drugs to neutralize toxin action, yielding a valuable adjunct to conventional antibiotic treatment.

引用

页码：539 / 541

页数：3

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