Interfacing Conducting Polymer Nanotubes with the Central Nervous System: Chronic Neural Recording using Poly (3,4-ethylenedioxythiophene) Nanotubes

被引：212

作者：

Abidian, Mohammad Reza ^{[1
]}

Ludwig, Kip A. ^{[1
]}

Marzullo, Timothy C. ^{[2
]}

Martin, David C. ^{[3
]}

Kipke, Daryl R. ^{[1
]}

机构：

[1] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Neurosci Program, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Dept Mat Sci & Engn, Ann Arbor, MI 48109 USA

来源：

ADVANCED MATERIALS | 2009年 / 21卷 / 37期

基金：

美国国家卫生研究院;

关键词：

MICROELECTRODE ARRAYS; ELECTRICAL-STIMULATION; BRAIN-TISSUE; POLY(3,4-ETHYLENEDIOXYTHIOPHENE); BIOCOMPATIBILITY; RESPONSES; ENCAPSULATION; DESIGN;

D O I：

10.1002/adma.200900887

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Microelectrodes implanted in the brain are increasingly being used to treat neurological disorders. However, robust and reliable chronic application of neural electrodes remains a challenge. Here, we report the use of conducting polymer nanotubes as highly selective neural interfaces for chronic neural recordings. Poly (3,4-ethylenedioxythiophene) nanotubes were formed on the chronic neural microelectrode. The quality of neuronal spike recordings was significantly improved relative to metal electrode sites.

引用

页码：3764 / 3770

页数：7

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