Comparison of external bulk video imaging with focused beam reflectance measurement and ultra-violet visible spectroscopy for metastable zone identification in food and pharmaceutical crystallization processes

被引：77

作者：

Simon, Levente L. ^{[2
]}

Nagy, Zoltan K. ^{[1
]}

Hungerbuhler, Konrad ^{[2
]}

机构：

[1] Univ Loughborough, Dept Chem Engn, Loughborough LE11 3TU, Leics, England

[2] Swiss Fed Inst Technol, Inst Chem & Bioengn, Zurich, Switzerland

来源：

CHEMICAL ENGINEERING SCIENCE | 2009年 / 64卷 / 14期

基金：

英国工程与自然科学研究理事会;

关键词：

Bulk video imaging; Metastable zone determination; Crystallization; Imaging; Pharmaceutical crystallization; Food crystallization; Instrumentation; COOLING CRYSTALLIZATION; LASER BACKSCATTERING; SHAPE DISTRIBUTIONS; CRYSTAL SIZE; WIDTH; TIME; VELOCITY; CHARTS;

D O I：

10.1016/j.ces.2009.04.016

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

The purpose of the paper is twofold: it describes the proof of concept of the newly introduced bulk video imaging (BVI) method and it presents the comparison with existing process analytical technologies (PAT) such as focused beam reflectance measurement (FBRM) and ultra-violet visible (UV/vis) spectroscopy. While the latter two sample the system in small volumes closely to the probe, the BVI approach monitors the entire or large parts of the crystallizer volume. The BVI method is proposed as a complementary noninvasive PAT tool and it is shown that it is able to detect the boundaries of the metastable zone with comparable or better performance than the FBRM and UV/vis probes. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：3344 / 3351

页数：8

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