From Progenitors to Differentiated Cells in the Vertebrate Retina

被引:189
作者
Agathocleous, Michalis [1 ,2 ]
Harris, William A. [1 ]
机构
[1] Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge CB2 3DY, England
[2] Univ Cambridge Gonville & Caius Coll, Cambridge CB2 1TA, England
基金
英国惠康基金;
关键词
lineage; stem cell; neuron; Muller glia; ciliary margin; INTERKINETIC NUCLEAR MIGRATION; ROD PHOTORECEPTOR DEVELOPMENT; CHROMATIN REMODELING COMPLEX; GANGLION-CELLS; STEM-CELLS; MULLER GLIA; EYE DEVELOPMENT; SONIC HEDGEHOG; FATE DETERMINATION; XENOPUS-LAEVIS;
D O I
10.1146/annurev.cellbio.042308.113259
中图分类号
Q2 [细胞生物学];
学科分类号
071013 [干细胞生物学];
摘要
Multipotent retinal progenitors undergo a varied number of divisions to produce clones of heterogeneous sizes and cell types. We describe the transition from a proliferating progenitor to a differentiated post-mitotic cell and discuss how controls of proliferation operate within individual cells as well as in the whole tissue. We discuss how extracellular and intracellular signaling, transcriptional regulation, cell cycle kinetics, interkinetic nuclear migration, orientation of cell division, and epigenetic modifications all interact to regulate a progenitor's transition from division to differentiation. We also propose some directions for future research.
引用
收藏
页码:45 / 69
页数:25
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