Cell Signaling in Space and Time: Where Proteins Come Together and When They're Apart

被引：480

作者：

Scott, John D. ^{[1
]}

Pawson, Tony ^{[2
,3
]}

机构：

[1] Univ Washington, Sch Med, Howard Hughes Med Inst, Dept Pharmacol, Seattle, WA 98195 USA

[2] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada

[3] Univ Toronto, Dept Mol Genet, Toronto, ON M5S 1A8, Canada

来源：

SCIENCE | 2009年 / 326卷 / 5957期

关键词：

NF-KAPPA-B; UBIQUITIN-BINDING DOMAINS; MAP KINASE; STRUCTURAL BASIS; REGULATORY SUBUNITS; TYROSINE KINASE; ACTIVATION; SCAFFOLD; RECOGNITION; ACETYLATION;

D O I：

10.1126/science.1175668

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Signal transduction can be defined as the coordinated relay of messages derived from extracellular cues to intracellular effectors. More simply put, information received on the cell surface is processed across the plasma membrane and transmitted to intracellular targets. This requires that the activators, effectors, enzymes, and substrates that respond to cellular signals come together when they need to.

引用

页码：1220 / 1224

页数：5

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