In Vivo Parasitological Measures of Artemisinin Susceptibility

被引:128
作者
Stepniewska, Kasia [1 ,8 ]
Ashley, Elizabeth [1 ,2 ,8 ]
Lee, Sue J. [1 ,8 ]
Anstey, Nicholas [3 ,4 ]
Barnes, Karen I. [5 ]
Tran Quang Binh [6 ]
D'Alessandro, Umberto [7 ]
Day, Nicholas P. J. [1 ,8 ]
de Vries, Peter J. [10 ]
Dorsey, Grant [11 ,12 ,13 ]
Guthmann, Jean-Paul [14 ,15 ]
Mayxay, Mayfong [16 ,17 ]
Newton, Paul N. [17 ]
Olliaro, Piero [8 ,18 ]
Osorio, Lyda [20 ]
Price, Ric N. [3 ,4 ,8 ]
Rowland, Mark [9 ]
Smithuis, Frank
Taylor, Walter R. J. [18 ,19 ]
Nosten, Francois [1 ,2 ,8 ]
White, Nicholas J. [1 ,8 ]
机构
[1] Mahidol Univ, Mahidol Oxford Trop Med Res Unit, Bangkok 10400, Thailand
[2] Shoklo Malaria Res Unit, Mae Sot, Thailand
[3] Menzies Sch Hlth Res, Darwin, NT, Australia
[4] Royal Darwin Hosp, Darwin, NT, Australia
[5] Univ Cape Town, Dept Med, Div Clin Pharmacol, ZA-7925 Cape Town, South Africa
[6] Cho Ray Hosp, Ho Chi Minh City, Vietnam
[7] Inst Trop Med, B-2000 Antwerp, Belgium
[8] Univ Oxford, Ctr Trop Med, Oxford, England
[9] London Sch Hyg & Trop Med, London WC1, England
[10] Univ Amsterdam, Acad Med Ctr, Div Infect Dis Trop Med & AIDS, NL-1105 AZ Amsterdam, Netherlands
[11] Univ Calif San Francisco, San Francisco, CA 94143 USA
[12] Inst Rech Sci Sante, Bobo Dioulasso, Burkina Faso
[13] Uganda Malaria Surveillance Programme, Kampala, Uganda
[14] Epicentre, Paris, France
[15] Inst Veille Sanitaire, Paris, France
[16] Natl Univ Laos, Viangchan, Laos
[17] Univ Oxford, Wellcome Trust Mahosot Hosp, Trop Med Res Collaborat, Microbiol Lab,Mahost Hosp, Viangchan, Laos
[18] World Hlth Org Special Programme Res & Training T, Geneva, Switzerland
[19] Hop Cantonal Univ Geneva, Serv Med Int & Humanitaire, Geneva, Switzerland
[20] Ctr Int Entrenamiento & Invest Med, Cali, Colombia
基金
英国惠康基金;
关键词
PLASMODIUM-FALCIPARUM MALARIA; ARTESUNATE-MEFLOQUINE COMBINATION; ANTIMALARIAL-DRUGS; PHARMACODYNAMIC PROPERTIES; PARASITE CLEARANCE; RESISTANT MALARIA; THAILAND; EFFICACY; CAMBODIA; BORDER;
D O I
10.1086/650301
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Parasite clearance data from 18,699 patients with falciparum malaria treated with an artemisinin derivative in areas of low (n = 14,539), moderate (n = 2077), and high (n = 2083) levels of malaria transmission across the world were analyzed to determine the factors that affect clearance rates and identify a simple in vivo screening measure for artemisinin resistance. The main factor affecting parasite clearance time was parasite density on admission. Clearance rates were faster in high-transmission settings and with more effective partner drugs in artemisinin-based combination treatments (ACTs). The result of the malaria blood smear on day 3 (72 h) was a good predictor of subsequent treatment failure and provides a simple screening measure for artemisinin resistance. Artemisinin resistance is highly unlikely if the proportion of patients with parasite densities of <100,000 parasites/mu L given the currently recommended 3-day ACT who have a positive smear result on day 3 is <3%; that is, for n patients the observed number with a positive smear result on day 3 does not exceed. (n + 60)/24.
引用
收藏
页码:570 / 579
页数:10
相关论文
共 31 条
[11]  
HARINASUTA T, 1965, LANCET, V2, P657
[12]   The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria [J].
Lee, Sue J. ;
Stepniewska, Kasia ;
Anstey, Nicholas ;
Ashley, Elizabeth ;
Barnes, Karen ;
Binh, Tran Quang ;
D'Alessandro, Umberto ;
Day, Nicholas P. J. ;
de Vries, Peter J. ;
Dorsey, Grant ;
Guthmann, Jean-Paul ;
Mayxay, Mayfong ;
Newton, Paul ;
Nosten, Francois ;
Olliaro, Piero ;
Osario, Lyda ;
Pinoges, Loretxu ;
Price, Ric ;
Rowland, Mark ;
Smithuis, Frank ;
Taylor, Robert ;
White, Nicholas J. .
MALARIA JOURNAL, 2008, 7 (1)
[13]  
Newcombe RG, 1998, STAT MED, V17, P857, DOI 10.1002/(SICI)1097-0258(19980430)17:8<857::AID-SIM777>3.0.CO
[14]  
2-E
[15]   Evidence of Artemisinin-Resistant Malaria in Western Cambodia [J].
Noedl, Harald ;
Se, Youry ;
Schaecher, Kurt ;
Smith, Bryan L. ;
Socheat, Duong ;
Fukuda, Mark M. .
NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (24) :2619-2620
[16]   TREATMENT OF MULTIDRUG-RESISTANT PLASMODIUM-FALCIPARUM MALARIA WITH 3-DAY ARTESUNATE MEFLOQUINE COMBINATION [J].
NOSTEN, F ;
LUXEMBURGER, C ;
TERKUILE, FO ;
WOODROW, C ;
EH, JP ;
CHONGSUPHAJAISIDDHI, T ;
WHITE, NJ .
JOURNAL OF INFECTIOUS DISEASES, 1994, 170 (04) :971-977
[17]   Effects of artesunate-mefloquine combination on incidence of Plasmodium falciparum malaria and mefloquine resistance in western Thailand:: a prospective study [J].
Nosten, F ;
van Vugt, M ;
Price, R ;
Luxemburger, C ;
Thway, KL ;
Brockman, A ;
McGready, R ;
ter Kuile, F ;
Looareesuwan, S ;
White, NJ .
LANCET, 2000, 356 (9226) :297-302
[18]   World antimalarial resistance network I: Clinical efficacy of antimalarial drugs [J].
Price, Ric N. ;
Dorsey, Grant ;
Ashley, Elizabeth A. ;
Barnes, Karen I. ;
Baird, J. Kevin ;
d'Alessandro, Umberto ;
Guerin, Philippe J. ;
Laufer, Miriam K. ;
Naidoo, Inbarani ;
Nosten, Francois ;
Olliaro, Piero ;
Plowe, Christopher V. ;
Ringwald, Pascal ;
Sibley, Carol H. ;
Stepniewska, Kasia ;
White, Nicholas J. .
MALARIA JOURNAL, 2007, 6 (1)
[19]   Intercontinental spread of pyrimethamine-resistant malaria [J].
Roper, C ;
Pearce, R ;
Nair, S ;
Sharp, B ;
Nosten, F ;
Anderson, T .
SCIENCE, 2004, 305 (5687) :1124-1124
[20]   In vitro stage-specific sensitivity of Plasmodium falciparum to quinine and artemisinin drugs [J].
Skinner, TS ;
Manning, LS ;
Johnston, WA ;
Davis, TME .
INTERNATIONAL JOURNAL FOR PARASITOLOGY, 1996, 26 (05) :519-525