Magnetic bead manipulation in a sub-microliter fluid volume applicable for biosensing

被引：54

作者：

Derks, R. J. S.

Dietzel, A.

Wimberger-Friedl, R.

Prins, M. W. J.

机构：

[1] Eindhoven Univ Technol, Dept Mech Engn, NL-5600 MB Eindhoven, Netherlands

[2] Philips Res, Healthcare Devices & Instrumentat, NL-5656 AE Eindhoven, Netherlands

[3] Eindhoven Univ Technol, Dept Appl Phys, NL-5600 MB Eindhoven, Netherlands

来源：

MICROFLUIDICS AND NANOFLUIDICS | 2007年 / 3卷 / 02期

关键词：

magnetic bead manipulation; lab-on-a-chip bio-assay; transport acceleration; optical velocity measurement; bead chain formation;

D O I：

10.1007/s10404-006-0112-9

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Magnetic actuation principles using superparamagnetic beads suspended in a fluid are studied in this paper. An experimental setup containing a sub-microliter fluid volume surrounded by four miniaturized electromagnets was designed and fabricated. On the basis of optical velocity measurements, the induced behavior of single beads and ordered chains was analyzed and compared to a theoretical model. This research can be used to develop new techniques for accelerated transportation in lab-on-a-chip bio-assays.

引用

页码：141 / 149

页数：9

共 14 条

[1]

[Anonymous], KINEMATICS MIXING ST

[2]

Brenner H., 1965, Low Reynolds number hydrodynamics: with special applications to Particulate Media

[3] Magnetic bead handling on-chip: new opportunities for analytical applications [J].