High Levels of Chronic Immune Activation in the T-Cell Compartments of Patients Coinfected with Hepatitis C Virus and Human Immunodeficiency Virus Type 1 and on Highly Active Antiretroviral Therapy Are Reverted by Alpha Interferon and Ribavirin Treatment

被引：117

作者：

Gonzalez, Veronica D. ^{[1
]}

Falconer, Karolin ^{[2
]}

Blom, Kim G. ^{[1
]}

Reichard, Olle ^{[2
]}

Morn, Birgitte ^{[3
]}

Laursen, Alex Lund ^{[4
]}

Weis, Nina ^{[5
,6
]}

Alaeus, Annette ^{[2
]}

Sandberg, Johan K. ^{[1
]}

机构：

[1] Karolinska Univ Hosp Huddinge, Karolinska Inst, Dept Med, Ctr Infect Med, S-14186 Huddinge, Sweden

[2] Karolinska Univ Hosp Solna, Karolinska Inst, Dept Med, Infect Dis Unit, S-17176 Stockholm, Sweden

[3] Aalborg Univ Hosp, Dept Infect Dis, Aalborg, Denmark

[4] Aarhus Univ Hosp, Dept Infect Dis, DK-8000 Aarhus, Denmark

[5] Rigshosp, Dept Infect Dis, DK-2100 Copenhagen, Denmark

[6] Hvidovre Univ Hosp, Dept Infect Dis, Copenhagen, Denmark

来源：

JOURNAL OF VIROLOGY | 2009年 / 83卷 / 21期

基金：

瑞典研究理事会;

关键词：

MICROBIAL TRANSLOCATION; HCV/HIV-1; COINFECTION; PROGRESSION; HCV; INFECTION; SURVIVAL; HIV-1; PREDICTION; MORTALITY; RECOVERY;

D O I：

10.1128/JVI.01211-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Chronic immune activation is a driver of human immunodeficiency virus type 1 (HIV-1) disease progression. Here, we describe that subjects with chronic hepatitis C virus (HCV)/HIV-1 coinfection display sharply elevated immune activation as determined by CD38 expression in T cells. This occurs, despite effective antiretroviral therapy, in both CD8 and CD4 T cells and is more pronounced than in the appropriate monoinfected control groups. Interestingly, the suppression of HCV by pegylated alpha interferon and ribavirin treatment reduces activation. High HCV loads and elevated levels of chronic immune activation may contribute to the high rates of viral disease progression observed in HCV/HIV-1-coinfected patients.

引用

页码：11407 / 11411

页数：5

共 30 条

[1] Human immunodeficiency virus-related microbial translocation and progression of hepatitis C [J].

Balagopal, Ashwin ;

Philp, Frances H. ;

Astemborski, Jacquie ;

Block, Timothy M. ;

Mehta, Anand ;

Long, Ronald ;

Kirk, Gregory D. ;

Mehta, Shruti H. ;

Cox, Andrea L. ;

Thomas, David L. ;

Ray, Stuart C. .

GASTROENTEROLOGY, 2008, 135 (01) :226-233

[2] Increasing mortality due to end-stage liver disease in patients with human immunodeficiency virus infection [J].

Bica, I ;

McGovern, B ;

Dhar, R ;

Stone, D ;

McGowan, K ;

Scheib, R ;

Snydman, DR .

CLINICAL INFECTIOUS DISEASES, 2001, 32 (03) :492-497

[3] Elevated numbers of FcγRIIIA+ (CD16+) effector CD8 T cells with NK cell-like function in chronic hepatitis C virus infection [J].

Bjorkstrom, Niklas K. ;

Gonzalez, Veronica D. ;

Malmberg, Karl-Johan ;

Falconer, Karolin ;

Alaeus, Annette ;

Nowak, Greg ;

Jorns, Carl ;

Ericzon, Bo-Goran ;

Weiland, Ola ;

Sandberg, Johan K. ;

Ljunggren, Hans-Gustaf .

JOURNAL OF IMMUNOLOGY, 2008, 181 (06) :4219-4228

[4] Microbial translocation is a cause of systemic immune activation in chronic HIV infection [J].

Brenchley, Jason M. ;

Price, David A. ;

Schacker, Timothy W. ;

Asher, Tedi E. ;

Silvestri, Guido ;

Rao, Srinivas ;

Kazzaz, Zachary ;

Bornstein, Ethan ;

Lambotte, Olivier ;

Altmann, Daniel ;

Blazar, Bruce R. ;

Rodriguez, Benigno ;

Teixeira-Johnson, Leia ;

Landay, Alan ;

Martin, Jeffrey N. ;

Hecht, Frederick M. ;

Picker, Louis J. ;

Lederman, Michael M. ;

Deeks, Steven G. ;

Douek, Daniel C. .

NATURE MEDICINE, 2006, 12 (12) :1365-1371

[5]

Daar ES, 2001, J ACQ IMMUN DEF SYND, V26, P466, DOI 10.1097/00126334-200104150-00011

[6] Hepatitis c virus load is associated with human immunodeficiency virus type 1 disease progression in hemophiliacs [J].

Daar, ES ;

Lynn, H ;

Donfield, S ;

Gomperts, E ;

O'Brien, SJ ;

Hilgartner, MW ;

Hoots, WK ;

Chernoff, D ;

Arkin, S ;

Wong, WY ;

Winkler, CA .

JOURNAL OF INFECTIOUS DISEASES, 2001, 183 (04) :589-595

[7]

De Rosa Francesco G, 2006, J Infect, V53, pe215, DOI 10.1016/j.jinf.2006.01.023

[8] Immune activation set point during early FHV infection predicts subsequent CD4+ T-cell changes independent of viral load [J].

Deeks, SG ;

Kitchen, CMR ;

Liu, L ;

Guo, H ;

Gascon, R ;

Narváez, AB ;

Hunt, P ;

Martin, JN ;

Kahn, JO ;

Levy, J ;

McGrath, MS ;

Hecht, FM .

BLOOD, 2004, 104 (04) :942-947

[9] Emerging Concepts in the Immunopathogenesis of AIDS [J].

Douek, Daniel C. ;

Roederer, Mario ;

Koup, Richard A. .

ANNUAL REVIEW OF MEDICINE, 2009, 60 :471-484

[10] Spontaneous HCV clearance in HCV/HIV-1 coinfection associated with normalized CD4 counts, low level of chronic immune activation and high level of T cell function [J].

Falconer, Karolin ;

Gonzalez, Veronica D. ;

Reichard, Olle ;

Sandberg, Johan K. ;

Alaeus, Annette .

JOURNAL OF CLINICAL VIROLOGY, 2008, 41 (02) :160-163

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