Enhanced Antibacterial Activity of Bifunctional Fe3O4-Ag Core-Shell Nanostructures

被引:150
作者
Chudasama, Bhupendra [1 ]
Vala, Anjana K. [2 ]
Andhariya, Nidhi [2 ]
Upadhyay, R. V. [3 ]
Mehta, R. V. [2 ]
机构
[1] SV Natl Inst Technol, Dept Appl Phys, Surat 395007, India
[2] Bhavnagar Univ, Dept Phys, Bhavnagar 364022, Gujarat, India
[3] Charotar Univ Sci & Technol, PD Patel Inst Appl Sci, Changa 388421, India
关键词
Core-shell nanostructure; antimicrobial activity; minimum inhibitory concentration; phase transfer; SILVER NANOPARTICLES; ANTIMICROBIAL AGENTS; COMPLEXES; EXPOSURE; GOLD;
D O I
10.1007/s12274-009-9098-4
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
We describe a simple one-pot thermal decomposition method for the production of a stable colloidal suspension of narrowly dispersed superparamagnetic Fe3O4-Ag core-shell nanostructures. These biocompatible nanostructures are highly toxic to microorganisms. Antimicrobial activity studies were carried out on both Gram negative (Escherichia coli and Proteus vulgaris) and Gram positive (Bacillus megaterium and Staphylococcus aureus) bacterial strains. Efforts have been made to understand the underlying molecular mechanism of such antibacterial actions. The effect of the core-shell nanostructures on Gram negative strains was found to be better than that observed for silver nanoparticles. The minimum inhibitory concentration (MIC) values of these nanostructures were found to be considerably lower than those of commercially available antibiotics. We attribute this enhanced antibacterial effect of the nanostructures to their stability as a colloid in the medium, which modulates the phosphotyrosine profile of the bacterial proteins and arrests bacterial growth. We also demonstrate that these core-shell nanostructures can be removed from the medium by means of an external magnetic field which provides a mechanism to prevent uncontrolled waste disposal of these potentially hazardous nanostructures.
引用
收藏
页码:955 / 965
页数:11
相关论文
共 35 条
[1]   Toxicity of silver nanoparticles in zebrafish models [J].
Asharani, P. V. ;
Wu, Yi Lian ;
Gong, Zhiyuan ;
Valiyaveettil, Suresh .
NANOTECHNOLOGY, 2008, 19 (25)
[2]   Silver nanoparticles capped by oleylamine: Formation, growth, and self-organization [J].
Chen, Meng ;
Feng, Yong-Gang ;
Wang, Xia ;
Li, Ting-Cheng ;
Zhang, Jun-Yan ;
Qian, Dong-Jin .
LANGMUIR, 2007, 23 (10) :5296-5304
[3]   The increasing use of silver-based products as antimicrobial agents: a useful development or a cause for concern? [J].
Chopra, Ian .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2007, 59 (04) :587-590
[4]  
COHEN SY, 1993, RETINA-J RET VIT DIS, V13, P312
[5]   Exposure-related health effects of silver and silver compounds: A review [J].
Drake, PL ;
Hazelwood, KJ .
ANNALS OF OCCUPATIONAL HYGIENE, 2005, 49 (07) :575-585
[6]   PREPARATION AND CHARACTERIZATION OF BIMETALLIC PD-CU COLLOIDS BY THERMAL-DECOMPOSITION OF THEIR ACETATE COMPOUNDS IN ORGANIC-SOLVENTS [J].
ESUMI, K ;
TANO, T ;
TORIGOE, K ;
MEGURO, K .
CHEMISTRY OF MATERIALS, 1990, 2 (05) :564-567
[7]  
Feng QL, 2000, J BIOMED MATER RES, V52, P662, DOI 10.1002/1097-4636(20001215)52:4<662::AID-JBM10>3.0.CO
[8]  
2-3
[9]   Preparation and antibacterial activity of Fe3O4@Ag nanoparticles [J].
Gong, Ping ;
Li, Huimin ;
He, Xiaoxiao ;
Wang, Kemin ;
Hu, Jianbing ;
Tan, Weihong ;
Zhang, Shouchun ;
Yang, Xiaohai .
NANOTECHNOLOGY, 2007, 18 (28)
[10]   Molecular genetics - Silver as a biocide: Will resistance become a problem? [J].
Gupta, A ;
Silver, S .
NATURE BIOTECHNOLOGY, 1998, 16 (10) :888-888