Cyclic di-GMP Allosterically Inhibits the CRP-Like Protein (Clp) of Xanthomonas axonopodis pv. citri

被引：107

作者：

Leduc, Jason L. ^{[1
]}

Roberts, Gary P. ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Bacteriol, Madison, WI 53706 USA

来源：

JOURNAL OF BACTERIOLOGY | 2009年 / 191卷 / 22期

关键词：

GENE ACTIVATOR PROTEIN; RECEPTOR PROTEIN; CAMPESTRIS; BINDING; TRANSCRIPTION; VIRULENCE;

D O I：

10.1128/JB.00845-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The protein Clp from Xanthomonas axonopodis pv. citri regulates pathogenesis and is a member of the CRP (cyclic AMP receptor protein) superfamily. We show that unlike the DNA-binding activity of other members of this family, the DNA-binding activity of Clp is allosterically inhibited by its effector and that cyclic di-GMP serves as that effector at physiological concentrations.

引用

页码：7121 / 7122

页数：2

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