Biologically active, synthetic ion transporters

被引：94

作者：

Gokel, George W.

Carasel, I. Alexandru

机构：

[1] Univ Missouri, Dept Chem, St Louis, MO 63121 USA

[2] Washington Univ, Sch Med, Dept Chem, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Dept Mol Biol & Pharmacol, St Louis, MO 63110 USA

来源：

CHEMICAL SOCIETY REVIEWS | 2007年 / 36卷 / 02期

关键词：

D O I：

10.1039/b605910b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The compelling chemical goal of modeling protein channel behavior has led to synthetic compounds that are true ion channels. Although they largely lack the selectivity and sophistication of highly evolved proteins, they successfully perform a variety of biological functions. This tutorial review describes these novel structures and their activity in living systems. Different channel structures show antibacterial to anticancer activity when tested against a variety of cell types.

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页码：378 / 389

页数：12

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