The Role of PLZF in Human Myeloid Development

被引：13

作者：

Dick, John E.

Doulatov, Sergei

机构：

[1] Univ Hlth Network, Div Cell & Mol Biol, Toronto, ON, Canada

[2] Univ Toronto, Dept Mol Genet, Toronto, ON, Canada

来源：

HEMATOPOIETIC STEM CELLS VII | 2009年 / 1176卷

关键词：

myelopoiesis; human; PLZF; ACUTE PROMYELOCYTIC LEUKEMIA; ZINC-FINGER; RETROVIRAL TRANSDUCTION; STEM-CELLS; DIFFERENTIATION; EXPRESSION; PROTEIN; PROGENITORS; REPRESSION; PROGRAM;

D O I：

10.1111/j.1749-6632.2009.04965.x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Little is known of the molecular regulators that enable production of large numbers of mature human hematopoietic cells (similar to 10(12) cells daily) while at the same time ensuring that the progenitor pools are not depleted. At the same time, the system must remain sufficiently flexible to respond to conditions of increased cellular output such as during blood loss or infection. We have identified a key role for the transcription factor PLZF in both these processes.

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收藏

页码：150 / 153

页数：4

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