The Role of PLZF in Human Myeloid Development

被引：13

作者：

Dick, John E.

Doulatov, Sergei

机构：

[1] Univ Hlth Network, Div Cell & Mol Biol, Toronto, ON, Canada

[2] Univ Toronto, Dept Mol Genet, Toronto, ON, Canada

来源：

HEMATOPOIETIC STEM CELLS VII | 2009年 / 1176卷

关键词：

myelopoiesis; human; PLZF; ACUTE PROMYELOCYTIC LEUKEMIA; ZINC-FINGER; RETROVIRAL TRANSDUCTION; STEM-CELLS; DIFFERENTIATION; EXPRESSION; PROTEIN; PROGENITORS; REPRESSION; PROGRAM;

D O I：

10.1111/j.1749-6632.2009.04965.x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Little is known of the molecular regulators that enable production of large numbers of mature human hematopoietic cells (similar to 10(12) cells daily) while at the same time ensuring that the progenitor pools are not depleted. At the same time, the system must remain sufficiently flexible to respond to conditions of increased cellular output such as during blood loss or infection. We have identified a key role for the transcription factor PLZF in both these processes.

引用

收藏

页码：150 / 153

页数：4

相关论文

共 29 条

[11] SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RAR alpha) and PLZF-RAR alpha oncoproteins associated with acute promyelocytic leukemia [J].

Hong, SH ;

David, G ;

Wong, CW ;

Dejean, A ;

Privalsky, ML .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (17) :9028-9033

[12] Expression of TEL-JAK2 in primary human hematopoietic cells drives erythropoietin-independent erythropoiesis and induces myelofibrosis in vivo [J].

Kennedy, J. A. ;

Barabe, F. ;

Patterson, B. J. ;

Bayani, J. ;

Squire, J. A. ;

Barber, D. L. ;

Dick, J. E. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (45) :16930-16935

[13] Biology of hematopoietic stem cells and progenitors: Implications for clinical application [J].

Kondo, M ;

Wagers, AJ ;

Manz, MG ;

Prohaska, SS ;

Scherer, DC ;

Beilhack, GE ;

Shizuru, JA ;

Weissman, IL .

ANNUAL REVIEW OF IMMUNOLOGY, 2003, 21 :759-806

[14] The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions [J].

Kovalovsky, Damian ;

Uche, Olisambu U. ;

Eladad, Sonia ;

Hobbs, Robin M. ;

Yi, Woelsung ;

Alonzo, Eric ;

Chua, Kevin ;

Eidson, Maggie ;

Kim, Hye-Jung ;

Im, Jin S. ;

Pandolfi, Pier Paolo ;

Sant'Angelo, Derek B. .

NATURE IMMUNOLOGY, 2008, 9 (09) :1055-1064

[15] Induction of T-cell development from human cord blood hematopoietic stem cells by Delta-like 1 in vitro [J].

La Motte-Mohs, RN ;

Herer, E ;

Zúñiga-Pflücker, JC .

BLOOD, 2005, 105 (04) :1431-1439

[16] A three-step pathway comprising PLZF/miR-146a/CXCR4 controls megakaryopoiesis [J].

Labbaye, Catherine ;

Spinello, Isabella ;

Quaranta, Maria Teresa ;

Pelosi, Elvira ;

Pasquini, Luca ;

Petrucci, Eleonora ;

Biffoni, Mauro ;

Nuzzolo, Eugenia Rosa ;

Billi, Monia ;

Foa, Robin ;

Brunetti, Ercole ;

Grignani, Francesco ;

Testa, Ugo ;

Peschle, Cesare .

NATURE CELL BIOLOGY, 2008, 10 (07) :788-801

[17] Determinants of lymphoid-myeloid lineage diversification [J].

Laiosa, Catherine V. ;

Stadtfeld, Matthias ;

Graf, Thomas .

ANNUAL REVIEW OF IMMUNOLOGY, 2006, 24 :705-738

[18] Multilineage transcriptional priming and determination of alternate hematopoietic cell fates [J].

Laslo, Peter ;

Spooner, Chauncey J. ;

Warmflash, Aryeh ;

Lancki, David W. ;

Lee, Hyun-Jun ;

Sciammas, Roger ;

Gantner, Benjamin N. ;

Dinner, Aaron R. ;

Singh, Harinder .

CELL, 2006, 126 (04) :755-766

[19] Growth suppression by acute promyelocytic leukemia-associated protein PLZF is mediated by repression of c-myc expression [J].

McConnell, MJ ;

Chevallier, N ;

Berkofsky-Fessler, W ;

Giltnane, JM ;

Malani, RB ;

Staudt, LM ;

Licht, JD .

MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (24) :9375-9388

[20] Retroviral transduction of TLS-ERG initiates a leukemogenic program in normal human hematopoietic cells [J].

Pereira, DS ;

Dorrell, C ;

Ito, CY ;

Gan, OI ;

Murdoch, B ;

Rao, VN ;

Zou, JP ;

Reddy, ESP ;

Dick, JE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (14) :8239-8244