Synthesis and biological activity of a new anti-factor Xa pentasaccharide with a C-interglycosidic bond

被引：16

作者：

Helmboldt, A

Petitou, M

Mallet, JM

Herault, JP

Lormeau, JC

Driguez, PA

Herbert, JM

Sinay, P

机构：

[1] SANOFI RECH,HAEMOBIOL RES DEPT,F-31036 TOULOUSE,FRANCE

[2] ECOLE NORMALE SUPER,DEPT CHIM,URA CNRS 1686,F-75231 PARIS 05,FRANCE

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(97)00252-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A mixed synthetic C, O-pentasaccharide 17 has been synthesized and shown to display an anti-factor Xa activity similar to that of the corresponding O-pentasaccharide 18. 17 represents the first example of a synthetic C-oligosaccharidic mimetic eliciting a significant biological response. (C) 1997 Elsevier Science Ltd.

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页码：1507 / 1510

页数：4

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