Expression of complement messenger RNAs by human endothelial cells

被引：21

作者：

Klegeris, A

Bissonnette, CJ

Dorovini-Zis, K

McGeer, PL

机构：

[1] Univ British Columbia, Kinsmen Lab Neurol Res, Vancouver, BC V6T 1Z3, Canada

[2] Vancouver Gen Hosp, Dept Pathol & Lab Med, Vancouver, BC V5Z 1M9, Canada

来源：

BRAIN RESEARCH | 2000年 / 871卷 / 01期

关键词：

complement classical pathway; human brain; inflammation; polymerase chain reaction; vascular endothelium;

D O I：

10.1016/S0006-8993(00)02253-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study evaluated complement mRNA expression in human brain microvessel endothelial cells (HBMEC), human umbilical vein endothelial cells (HUVEC), and cells of the human derived ECV304 line. Cerebral endothelial cells and HUVEC expressed detectable levels of complement gene mRNAs for the C1q B-chain, C1r, C1s, C2, C3, C4, CS, C7, C8 gamma-subunit and C9. In addition to C6 mRNA, Clq and C9 were not detected in ECV304 cells. These results indicate that endothelial cells may be a source of complement proteins in brain and other organs of the body. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：1 / 6

页数：6

共 35 条

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